Table 1

Definitions included in the study

TypeDefinition
CMV replicationCan be diagnosed by growing the virus in vitro, finding evidence of viral infection by intra-cytoplasmic or intra-nuclear inclusions or by antibody-based staining techniques for CMV in histopathological sections or finding evidence of replication using nucleic acid based assays or antigenaemia studies.
CMV diseaseEvidence of CMV infection with attributable symptoms. CMV disease can be sub-classified into CMV viral syndrome or tissue invasive disease.
Definitive diagnosis of CMV pneumonia must be based on the histological demonstration of CMV invasive disease. Nevertheless, for this study we also accept the evidence of CMV infection (including detection of CMV-DNA in bronchoalveolar lavage (BAL)) with attributable symptoms once other potential causes has been ruled out.
  • CMV, cytomegalovirus.