Table 1

Inclusion and exclusion criteria

Inclusion criteria
  • 5–17 years old

  • *Diagnosis of MCS or VS based on clinical evaluation by the inpatient neuropsychology team47

  • Hearing test completed as part of clinical care

  • Parent/guardian must be proficient in English

  • Parent/guardian report that the child demonstrated proficiency in English prior to acquired brain injury

Exclusion criteria
  • Presence of extensive focal lesions in the left dorsolateral prefrontal cortex as determined by review of imaging/imaging reports obtained as part of clinical care

  • Known seizures in the prior month

  • Non-conclusive seizures and/or interictal epileptiform discharges observed on any study EEG

  • History of craniotomy

  • Presence of metallic cerebral, cochlear or electronic implant or ventricular shunt or pacemaker

  • Presence of skin lesion, severe rash or open wounds

  • Children with head circumference less than 43 cm

  • Bilateral severe or profound hearing loss

  • Presence of hairstyle interfering with tDCS application and/or high-quality EEG signal

  • Females with confirmed pregnancy

  • Youth on daytime mechanical ventilation

  • Youth in foster care

  • *Children meeting criteria on the CRS-R for any of the items indicating MCS but not items indicating conscious state will be considered to be in MCS. Children not meeting criteria for MCS will be considered in VS.

  • CRS-R, Coma Recovery Scale-Revised; EEG, electroencephalography; MCS, minimally conscious state; VS, vegetative state; tDCS, transcranial direct current stimulation.