Table 1

Baseline characteristics of the population by tertile of ALP, median (IQR), or N (%), or means±SD

VariableOverall (n=6368)Tertile 1
ALP<66 U/L
(n=2123)
Tertile 2
ALP 66–85 U/L
(n=2123)
Tertile 3
ALP>85 U/L
(n=2122)
P value
Demographics
 Age, years62.2±11.362.6±11.362.0±11.462.0±11.30.229
 Male4379 (68.8)1581 (74.5)1461 (68.8)1337 (63.0)<0.001
Medical history
 History of diabetes mellitus2036 (32.0)668 (31.5)718 (33.8)650 (30.6)0.069
 History of hypertension3816 (59.9)1263 (59.5)1259 (59.3)1294 (61.0)0.474
 History of MI614 (9.6)208 (9.8)218 (10.3)188 (8.9)0.286
 Dyslipidaemia4256 (66.8)1407 (66.3)1417 (66.7)1432 (67.5)0.701
 Prior PCI702 (11.0)246 (11.6)247 (11.6)209 (9.8)0.106
 Current smoking2839 (44.6)928 (43.7)957 (45.1)954 (45.0)0.612
Clinical presentation
 SBP on admission, mm Hg135.3±21.9134.1±21.7135.8±22.3135.9±21.80.019
 Heart rate on admission, bpm74.9±14.073.7±13.675.2±13.875.6±14.4<0.001
 GRACE score129.1±36.6128.7±37.4129.0±35.9129.7±36.50.727
 Diagnosis on admission0.001
 STEMI2207 (34.7)710 (33.4)723 (34.1)774 (36.5)
 NSTEMI-ACS4161 (65.3)1413 (66.6)1400 (65.9)1348 (63.5)
Laboratory results on admission
 Troponin-I, ng/mL0.40 (0.01, 11.08)0.22 (0.01, 10.38)0.44 (0.01, 10.29)0.67 (0.01, 12.35)0.001
 Creatinine, umol/L72 (61, 85)73 (63, 87)72 (61, 84)71 (59, 85)<0.001
 Albumin, g/L39.5±3.939.1±3.739.6±3.639.8±4.3<0.001
 SGOT, U/L30 (19, 90)28 (18, 81)28 (18, 85)35 (21, 104)<0.001
 SGPT, U/L28 (17, 48)26 (17, 45)26 (17, 44)33 (20, 55)<0.001
 ALP, U/L77.3±24.353.6±9.774.6±5.5103.6±19.7<0.001
 Haemoglobin, g/L136.2±17.4135.4±16.6136.3±17.4136.7±18.00.017
 Leucocyte count (×109/L)8.25±3.247.89±3.118.20±2.858.68±3.63<0.001
 Platelet count (×109/L)205.4±59.6197.6±58.4204.3±56.2214.3±62.9<0.001
 BNP, ng/L122 (42, 338)121 (42, 338)116 (41, 313)128 (43, 356)0.168
Percutaneous coronary intervention details
 Moderate or severe calcification400 (6.3)110 (5.2)141 (6.6)149 (7.0)0.034
 Left main disease553 (8.7)186 (8.8)195 (9.2)172 (8.1)0.453
 Three-vessel disease1636 (25.7)555 (26.1)563 (26.5)518 (24.4)0.245
 Use of intra-aortic balloon pump192 (3.0)63 (3.0)66 (3.1)63 (3.0)0.953
 TIMI flow grade 0/1 on arrival4930 (77.4)1684 (79.3)1640 (77.2)1606 (75.7)0.018
 TIMI flow grade three post PCI6342 (99.6)2112 (99.5)2115 (99.6)2115 (99.7)0.606
 Duration of hospitalisation, days7.5±4.47.4±4.17.6±4.67.5±4.50.871
 In-hospital mortality55 (0.9)15 (0.7)29 (1.4)0.007
  • ALP, alkaline phosphatase; BNP, brain natriuretic peptide;MI, myocardial infarction; NSTEMI-ACS, non-ST-segment elevation myocardial infarction of acute coronary syndrome; PCI, percutaneous coronary intervention; SBP, systolic blood pressure; SGOT, serum glutamic oxaloacetic transaminase; SGPT, serum glutamate-pyruvate transaminase; STEMI, ST-segment elevation myocardial infarction;TIMI, thrombolysis in myocardial infarction; bpm, beats per minute.