Measures to be employed in the study
| Function | Outcome measure | Ref. | ||
| Primary outcome | Executive functioning (EF) | Q | Behavioral Rating Inventory of Executive Function, parent report (BRIEF) | 66 |
| Secondary outcome, specific to EF | EF | Q | BRIEF, self- and teacher report | 66 |
| Q | Dysexecutive Questionnaire for Children (DEX-C), parent- and teacher report | 80 | ||
| Q | ADHD Rating Scale IV, parent and teacher report | 81 | ||
| NP | Conners Continuous Performance Test third edition (CPT-III) | 82 | ||
| NP | Color-Word Interference Test (CWIT 3–4), Delis-Kaplan Executive Function System (D-KEFS) | 83 | ||
| NP | Behavioural Assessment of the Dysexecutive Syndrome in Children (BADS-C) | 80 | ||
| NP | Tower of London (TOL) | 84 | ||
| NP | Trail Making Test 3–4 (TMT 3–4), D-KEFS | 83 | ||
| OA | Children’s Cooking Task (CCT) | 77 | ||
| Secondary outcome related to other functions/domains | Motor function | NP | Grooved pegboard | 85 |
| Processing speed | NP | Coding & Symbol search, WISC-V | 74 | |
| NP | Trail Making Test (TMT 1–2), D-KEFS | 83 | ||
| NP | Color-Word Interference Test (CWIT 1–2), D-KEFS | |||
| Working memory | NP | Digit Span, Picture Span, WISC-V | 74 | |
| Verbal learning & memory | NP | Childrens Auditory Verbal Learning Test (CAVLT-2) | 86 87 | |
| Social Cognition | NP | Mentalization, NEPSY-II second edition (NEPSY - II) | 88 | |
| Q | Achenbach System of Empirically Based Assessment (ASEBA) | 89 | ||
| Sosio-emotional function | Q | Harter Self Perception Profile for Children and Adolescents (SPPC-R and SPPA-R) | 90 | |
| Self-esteem /self-efficacy | Q | Paediatric Quality of Life Inventory (PedsQL) | 90 | |
| Quality of life | PedsQL Fatigue scale | 91 | ||
| Fatigue | Q | Health Behaviour Inventory | 92 | |
| Adaptive and daily living skills | Q | Family Functioning Scales | 93 | |
| Family & Environment | Q | Center for Epidemiologic Studies Depression Scale (CESD) | 94 | |
| Health outcome | Q | Glasgow Outcome Scale Extended Paediatric (GOS-E Peds) | 95 | |
| CI | EQ-5D-Y | |||
| Q | ||||
| Baseline variables/ demographics | General ability | NP | Vocabulary, Similarities, Block Design, Matrix Reasoning, Wechsler Intelligence Scale for Children fifth edition (WISC-V) | 74 |
| Clinical assessment | CI | Clinical and neurological examination with evaluation of hormonal status in peripheral blood as indicated Standardised interview |
CI, clinical interview; NP, neuropsychological tests; OA, observational assessment tool; Q, questionnaire.