Table 4

Sensitivity analysis: PSW-adjusted HR by Cox proportional HR regression

	Any length of metformin vs none		Metformin ≤2 years vs none		Metformin >2 years vs none
	aHR*	95% CI	aHR*	95% CI	aHR*	95% CI
ND	0.69	0.57 to 0.85	1.00	0.80 to 1.26	0.39	0.29 to 0.52
Dementia	0.63	0.50 to 0.79	0.90	0.69 to 1.18	0.36	0.26 to 0.50
PD	0.63	0.41 to 0.96	1.04	0.65 to 1.65	0.30	0.15 to 0.58
AD§	1.03	0.63 to 1.69	1.71	0.99 to 2.93	0.39	0.18 to 0.85
Mild cognitive impairment	1.13	0.45 to 2.82	1.12	0.36 to 3.49	1.00	0.34 to 2.94

*Non-metformin treatment cohort was the reference group for adjusted HR (aHR) estimation.
AD, Alzheimer’s disease; ND, neurodegenerative disease; PD, Parkinson’s disease; PSW, propensity score weight.