Table 3

PSW-adjusted HR by Cox proportional HR regression

	Length of metformin exposure
	≤1 year vs no		1–2 years vs no		2–4 years vs no		>4 years vs no
	aHR*	95% CI	aHR*	95% CI	aHR*	95% CI	aHR*	95% CI
ND	1.16	0.89 to 1.51	0.80	0.56 to 1.13	0.62	0.45 to 0.85	0.19	0.12 to 0.31
Dementia	0.88	0.64 to 1.21	1.02	0.72 to1.44	0.55	0.38 to 0.79	0.22	0.13 to 0.37
PD	1.51	0.93 to 2.46	0.56	0.24 to 1.31	0.59	0.29 to 1.17	0.04	0.00 to 0.37
AD	2.19	1.21 to 3.94	0.86	0.33 to 2.21	0.63	0.26 to 1.50	0.17	0.04 to 0.70
Mild cognitive impairment†	0.86	0.19 to 3.81	1.50	0.36 to 6.19	1.43	0.41 to 4.95	0.78	0.19 to 3.19

*Non-metformin treatment cohort was the reference group for adjusted HR (aHR) estimation.
†Bad estimation due to small number of events.
AD, Alzheimer’s disease; ND, neurodegenerative disease; PD, Parkinson’s disease; PSW, propensity score weight.