Table 3

Univariate logistic regression showing significant predictors of ACS in patients with chest pain

VariablesTotal cohort (n=2773)
OR (95% CI)P value
Age1.00 (0.99 to 1.02)0.476
Gender1.33 (1.04 to 1.71)0.027
Diabetes1.02 (0.78 to 1.31)0.890
Hypertension1.36 (1.07 to 1.73)0.012
Current smoker1.66 (1.29 to 2.11)<0.001
TG*1.40 (1.15 to 1.70)<0.001
TC*5.17 (3.30 to 8.15)<0.001
HDL-C*0.44 (0.30 to 0.66)<0.001
LDL-C*3.14 (2.37 to 4.17)<0.001
ApoA1*0.17 (0.09 to 0.29)<0.001
ApoB*2.83 (2.05 to 4.01)<0.001
ApoE*0.93 (0.76 to 1.17)0.534
Lp(a)*1.10 (1.00 to 1.21)0.055
NTproBNP*1.73 (1.61 to 1.88)<0.001
CRP*1.74 (1.59 to 1.90)<0.001
hs-cTnT*2.45 (2.24 to 2.70)<0.001
Cer(d18:1/16:0)*7.53 (5.11 to 11.17)<0.001
Cer(d18:1/18:0)*4.67 (3.55 to 6.17)<0.001
Cer(d18:1/24:0)*1.41 (1.05 to 1.90)0.025
Cer(d18:1/24:1(15Z))*5.09 (3.79 to 6.87)<0.001
Cer(d18:1/14:0)*2.04 (1.59 to 2.62)<0.001
Cer(d18:1/20:0)*4.55 (3.35 to 6.22)<0.001
Cer(d18:1/22:0)*2.36 (1.75 to 3.18)<0.001
Cer(d18:0/16:0)*2.02 (1.61 to 2.55)<0.001
Cer(d18:0/18:0)*2.26 (1.92 to 2.66)<0.001
Cer(d18:0/24:0)*1.49 (1.21 to 1.84)<0.001
Cer(d18:0/24:1(15Z))*2.73 (2.24 to 3.33)<0.001
Cer(d18:1/24:1)*1.57 (1.26 to 1.96)<0.001
Cer(d18:1/16:0)/Cer(d18:1/24:0)*4.11 (2.87 to 5.89)<0.001
Cer(d18:1/18:0)/Cer(d18:1/24:0)*3.84 (2.93 to 5.05)<0.001
Cer(d18:1/24:1(15Z))/Cer(d18:1/24:0)*2.63 (2.08 to 3.34)<0.001
  • Data are OR (95% CI).

  • *Log transformed before analysis.

  • ACS, acute coronary syndrome; ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; ApoE, apolipoprotein E; Cer, ceramides; CRP, C reactive protein; HDL-C, high-density lipoprotein cholesterol; hs-cTnT, high-sensitivity cardiac troponin T; LDL-C, low-density lipoprotein cholesterol; LP(a), lipoprotein(a); NTproBNP, N-terminal pro-brain natriuretic peptide; TC, total cholesterol; TG, triglyceride.