Table 2

Plasma levels of ceramides molecules and ratios in total cohort and by ACS status

Ceramides (μmol/L)Total cohort (n=2773)non-ACS (n=2419)ACS (n=354)P value
Cer(d18:1/16:0)0.203 (0.165–0.248)0.198 (0.162–0.241)0.237 (0.203–0.286)<0.001
Cer(d18:1/18:0)0.051 (0.037–0.069)0.049 (0.036–0.065)0.068 (0.051–0.084)<0.001
Cer(d18:1/24:0)2.065 (1.607–2.680)2.053 (1.592–2.672)2.164 (1.675–2.757)0.028
Cer(d18:1/24:1(15Z))0.583 (0.448–0.767)0.569 (0.436–0.739)0.730 (0.557–0.950)<0.001
Cer(d18:1/14:0)0.0027 (0.0020–0.0036)0.0027 (0.0020–0.0035)0.0030 (0.0024–0.0040)<0.001
Cer(d18:1/20:0)0.053 (0.040–0.067)0.051 (0.039–0.065)0.063 (0.051–0.078)<0.001
Cer(d18:1/22:0)0.381 (0.300–0.490)0.375 (0.294–0.480)0.416 (0.336–0.540)<0.001
Cer(d18:0/16:0)0.010 (0.007–0.014)0.010 (0.007–0.013)0.011 (0.008–0.015)<0.001
Cer(d18:0/18:0)0.005 (0.003–0.008)0.005 (0.003–0.007)0.007 (0.004–0.011)<0.001
Cer(d18:0/24:0)0.061 (0.042–0.086)0.060 (0.042–0.086)0.068 (0.048–0.094)<0.001
Cer(d18:0/24:1(15Z))0.029 (0.020–0.044)0.028 (0.019–0.041)0.040 (0.026–0.058)<0.001
Cer(d18:1/24:1)0.262 (0.195–0.375)0.258 (0.192–0.372)0.298 (0.221–0.386)<0.001
Ceramides ratio
 Cer(d18:1/16:0)/Cer(d18:1/24:0)0.096 (0.080–0.116)0.095 (0.079–0.114)0.107 (0.090–0.132)<0.001
 Cer(d18:1/18:0)/Cer(d18:1/24:0)0.024 (0.019–0.032)0.023 (0.018–0.031)0.031 (0.023–0.039)<0.001
 Cer(d18:1/24:1(15Z))/Cer(d18:1/24:0)0.269 (0.214–0.360)0.261 (0.211–0.345)0.321 (0.253–0.426)<0.001
  • Data are median (IQR).

  • P value for the difference between patients diagnosed as ACS and non-ACS.

  • ACS, acute coronary syndrome.