Table 5

Discrimination and reclassification of ACS with various multivariable logistic regression models

Old modelNew modelAUC (95% CI)P value-AUCNRI (95% CI)P value-NRI
Traditional factors*-0.78 (0.75 to 0.81)---
hs-cTnT-0.80 (0.77 to 0.83)---
Traditional factors*+hs-cTnT0.81 (0.78 to 0.84)0.220 0.52 (0.40 to 0.64) <0.001
Traditional factors*+Ceramides† 0.81 (0.78 to 0.84) <0.001 0.35 (0.23 to 0.47) <0.001
Traditional factors* +hs-cTnT+Ceramides† 0.87 (0.84 to 0.89) <0.001 0.51 (0.39 to 0.64) <0.001
  • P values AUC and p values NRI are for the difference between old models and new models. Bold used to highlight those p values <0.05.

  • *Traditional risk factors include hypertension, current smoker, LDL-C, CRP and NTproBNP levels.

  • †Ceramides include Cer(d18:1/24:1(15Z))/Cer(d18:1/24:0), Cer(d18:1/14:0) and Cer(d18:1/22:0).

  • LDL-C, CRP, NT-proBNP, hs-cTnT and ceramides levels are log transformed before analysis.

  • ACS, acute coronary syndrome; CRP, C reactive protein; hs-cTnT, high-sensitivity cardiac troponin T; LDL-C, low-density lipoprotein cholesterol; NT-proBNP, N-terminal pro-brain natriuretic peptide.