Table 4

Multivariable logistic regression showing significant predictors of ACS in patients with chest pain after adjustment for conventional risk factors

Baseline variablesModel 1Model 2Model 3Model 4Model 5
Hypertension1.37 (1.03 to 1.83)*1.35 (0.98 to 1.87)1.41 (1.06 to 1.90)*1.40 (1.01 to 1.96)*
Current smoker1.93 (1.43 to 2.58)***1.52 (1.09 to 2.10)*1.99 (1.47 to 2.69)***1.58 (1.12 to 2.21)**
LDL-C†2.63 (1.91 to 3.64)***2.01 (1.42 to 2.87)***2.13 (1.51 to 3.04)***1.64 (1.12 to 2.41)*
CRP†1.40 (1.27 to 1.55)***1.20 (1.07 to 1.34)**1.38 (1.25 to 1.53)***1.16 (1.03 to 1.31)*
NTproBNP†1.63 (1.49 to 1.78)***1.16 (1.04 to 1.29)**1.57 (1.44 to 1.72)***1.07 (0.95 to 1.19)
hs-cTnT†2.45 (2.24 to 2.70)***2.02 (1.80 to 2.27)***2.19 (1.94 to 2.49)***
Cer(d18:1/24:1(15Z))/
Cer(d18:1/24:0)†
2.96 (2.16 to 4.07)***4.46 (3.11 to 6.40)***
Cer(d18:1/14:0)†1.44 (1.01 to 2.06)*1.74 (1.17 to 2.61)**
Cer(d18:1/22:0)†2.08 (1.32 to 3.29)**2.30 (1.37 to 3.87)**
  • Data are OR (95% CI).

  • Model 1. Included traditional risk factors (hypertension, current smoker, LDL-C, CRP and NTproBNP levels).

  • Model 2. Only Included hs-cTnT.

  • Model 3. Included traditional risk factors and hs-cTnT.

  • Model 4. Included traditional risk factors and ceramides.

  • Model 5. Included traditional risk factors, hs-cTnT and ceramides.

  • *P<0.05, **p<0.01, ***p<0.001.

  • †Log transformed before analysis.

  • ACS, acute coronary syndrome; Cer, ceramides; CRP, C reactive protein; hs-cTnT, high-sensitivity cardiac troponin T; LDL-C, low-density lipoprotein cholesterol; NTproBNP, N-terminal pro-brain natriuretic peptide.