Table 1

Difference in demographics and risk factors between patients with known AF and newly diagnosed AF

VariableAll patients (n=1470)Newly diagnosed AF (n=999)Known AF (n=471)P value
Age, (SD)76 (10)75 (10)77 (11)0.04
Age (SD) in those with only one risk factor other than sex68 (8)67 (8)66 (7)0.501
Sex, female, n (%)622 (42)404 (40)218 (46)0.034
Known hypertension,n (%)915 (63)594/983 (60)321/465 (69)0.002
Known diabetes mellitus, n (%)243/1469 (17)164/998 (16)79 (17)0.87
Known hyperlipidaemia, n (%)649/1449 (45)421/986 (43)228/463 (49)0.019
Current smoker, n(%)165/1425 (12)114/968 (12)51/461 (11)0.674
Excessive alcohol, n(%)110/1365 (8)79/929 (9)31/436 (7)0.378
Prestroke mRS, median (IQR)0 (0 to 0)0 (0 to 0)0 (0 to 1)0.002
Dependant living n (%)97/1435 (7)58/974 (6)39/461 (8)0.076
Previous ischaemic stroke n(%)141/1445 (10)94/977 (10)47/468 (10)0.801
Previous ICH n(%)8/1450 (0.5)5/981 (0.5)3/469 (0.6)0.719
Ischaemic heart disease n(%)241 (16)137 (14)104 (22)<0.001
Known dementia/cognitive impairment n(%)37/1463 (3)18/996 (2)19/467 (4)0.010
Known peripheral vascular disease n (%)31/1445 (2)19/990 (2)12/464 (3)0.412
Antiplatelets on admission, n (%)765/1455 (53)423/986 (43)342/469 (73)<0.001
Cerebral microbleeds, presence, n (%)308 (21)207 (21)101 (21)0.751
Confluent white matter hyperintensities, presence, n (%)428 (29)281 (28)147 (31)0.225
Cortical superficial siderosis, presence, n (%)5 (0.3)5 (0.5)0 (0.0)0.183
Prestroke CHA2DS2-VASc, median, (IQR)
(available in 1374 patients)
3 (2 to 4)3 (2 to 4)3 (2 to 4)0.001
CHA2DS2-VASc score≥1 n (%)1306/1374 (95)877/927 (95)429/447(96)0.274
CHA2DS2-VASc score reaching evidence for recommended oral anticoagulation (class 1a evidence), n (%)895/1374 (65)591/927 (64)304/447 (68)0.121
CHA2DS2-VASc score reaching evidence for consideration of oral anticoagulation (class 2b evidence) n (%)1182/1374 (86)786/927 (85)396/447 (89)0.057
Prestroke HAS-BLED median (IQR) (available in 1280 patients)3 (2 to 3)2 (2 to 3)3 (2 to 3)0.010
  • AF, atrial fibrillation; ICH, intracerebral haemorrhage; mRS, modified Rankin Scale.