CVD events | HR (95% CI) p value | ||||
n (%) | Unadjusted model (1) | Adjusted model (2) | Adjusted model (3) | Adjusted model (4) | |
Continuous RRDI (10-unit increment) | 24/569 (4) | 1.24 (1.10 to 1.39) 0.0003 | 1.22 (1.08 to 1.38) 0.0018 | 1.23 (1.11 to 1.38) 0.0007 | 1.22 (1.08 to 1.37) 0.0012 |
RRDI Category | |||||
Tertile 1 (<15.1) | 3/187 (2) | REF | REF | REF | REF |
Tertile 2 (15.1–<28.4) | 7/194 (4) | 2.66 (0.68 to 10.34) 0.1586 | 2.72 (0.70 to 10.59) 0.1481 | 3.16 (0.81 to 12.40) 0.099 | 3.22 (0.80 to 12.93) 0.10 |
Tertile 3 (≥28.4) | 14/188 (7) | 6.11 (1.72 to 21.72) 0.0052 | 5.87 (1.60 to 21.46) 0.0075 | 7.40 (1.97 to 27.73) 0.003 | 8.99 (2.35 to 34.40) 0.001 |
P-trend | 0.0024 | 0.0045 | 0.0017 | 0.0006 |
Model (1) is unadjusted. Model (2) is adjusted for age, sex and body mass index. Model (3) is additionally adjusted for age, sex, body mass index and AHI (4% criteria). Model (4) is additionally adjusted for diabetes, HTN, stroke and smoking, average HR and %TST<90%.
AHI 4%, apnoea–hypopnoea index with hypopnoea scored if associated with at least 4% desaturation (events/hour); CVD, cardiovascular disease; HTN, hypertension; RRDI, R-R interval dips index (dips/hour); %TST<90, total sleep time spent less than 90% on oxygen saturation signal (%).