Table 1

Inclusion and exclusion criteria Reduction of intravenous Antibiotics In Neonates study

Inclusion criteriaExclusion criteria
  • Neonates, postmenstrual age ≥35+0 weeks, postnatal age of 0–28 days, body weight ≥2 kg.

  • Probable bacterial infection defined as clinical symptoms and/or maternal risk factors and elevated inflammatory markers for which empiric broad-spectrum antibiotic treatment was initiated and needs to be continued for >48 hours.

  • Clinically well.

  • Tolerate oral feeding without overt vomiting.

  • Proven bloodstream infection.

  • Absence of blood culture.

  • Severe localised infection (meningitis, osteomyelitis, necrotising enterocolitis).

  • Severe clinical sepsis (compromised circulation, need for mechanical ventilation).

  • Continuous need for a central venous line.

  • Severe hyperbilirubinaemia exceeding the exchange level.

  • Parents’ inability to administer medication.