Table 1

Summary of prior selected studies that reported adverse events related to NO administration

AuthorsPatients (n)Age group (newborn, paediatric, adult)NO (ppm)Time of exposureAdverse events
Van Meurs et al 68 210Premature newborns <34 weeks gestational age (26±2 gestational weeks)5–1010–14 hoursNO>5 ppm in two infants; Met-Hb >8% in one infant. No resulting complications were reported.
Stork et al 69 114Newborn >34 gestational weeks and <14 days old (39.3±1.8 gestational weeks)20–80<14 daysMet-Hb >5% in 11 infants. No resulting complications were reported. A dose of 100 ppm NO was given to two infants for 36 and 60 min, respectively. NO2 levels in the second infant elevated to 5.1 ppm. NO2 and Met-Hb levels decreased after NO concentration returned to 80 ppm.
Roberts et al 70 30Newborns >37 gestational weeks (39.8±1.5 gestational weeks)80<8.5 daysMet-Hb elevated to 18.2% in one infant. The later clinical course was uneventful.
James et al 71 101Paediatric (1–43 months old)201–3 hoursNone related to NO delivery.
Cueto et al 72 40Paediatric (15 days old–17 years old)4–30hours to daysRebound effects of NO withdrawal reported in two patients.
Lei et al 17 117Adult >18 years old
(48.7±9.5 years old)
8024 hoursNone related to NO delivery.
Rossaint et al 73 9Adult (17–46 years old)5–203–53 daysNone related to NO delivery.
Taylor et al 74 192Adult >18 years old (50±17 years old)5<28 days66 reported infections in the NO group and 41 in the control group. Infections deemed unrelated to NO gas administration. No further complications were reported.
  • Data of age are presented as mean±SD or range.

  • Met-Hb, ferric methaemoglobin; NO, nitric oxide; NO2, nitrogen dioxide.