Table 3

Incidence rates, HRs and associated 95% CIs for ALS and other MND, comparing men in the BPH cohort to men in a matched general population cohort

ALS and other MND, NIncidence rate per 1000 person-years (95% CI)HR (95% CI)
UnadjustedAdjusted*
Follow-up period
0–34 years
 Comparison cohort1094†0.12 (0.12 to 0.13)ReferenceReference
 BPH cohort227†0.13 (0.11 to 0.15)1.04 (0.89 to 1.21)1.05 (0.90 to 1.22)
0–2 years
 Comparison cohort2460.12 (0.11 to 0.14)ReferenceReference
 BPH cohort570.14 (0.11 to 0.18)1.18 (0.89 to 1.58)1.20 (0.90 to 1.61)
>2–10 years
 Comparison cohort5700.12 (0.11 to 0.13)ReferenceReference
 BPH cohort1170.12 (0.10 to 0.15)1.07 (0.87 to 1.32)1.08 (0.88 to 1.33)
>10–34 years
 Comparison cohort2780.15 (0.13 to 0.17)ReferenceReference
 BPH cohort530.13 (0.10 to 0.17)0.82 (0.58 to 1.15)0.82 (0.58 to 1.16)
Year of BPH diagnosis
1980–1993
 Comparison cohort4790.11 (0.10 to 0.12)ReferenceReference
 BPH cohort1030.12 (0.10 to 0.15)1.07 (0.85 to 1.35)1.06 (0.84 to 1.34)
1994–2013
 Comparison cohort6150.13 (0.12 to 0.15)ReferenceReference
 BPH cohort1240.14 (0.11 to 0.16)1.02 (0.83 to 1.25)1.03 (0.84 to 1.26)
  • *Adjusted for diagnoses of diabetes mellitus, obesity, hypertension and hyperlipidaemia.

  • †For ALS and other MND, the most common ICD-8 diagnosis was ALS (156 in the comparison cohort, 42 in the BPH cohort), and the most common ICD-10 diagnosis was MND (763 in the comparison cohort, 149 in the BPH cohort). Other ICD-8 diagnoses in these cohorts were other and unspecified MND (37), progressive bulbar paralysis (20), progressive spinal paralysis (10) and other progressive muscular atrophy (2). Other ICD-10 diagnoses were ALS (129), progressive bulbar paralysis (8), progressive spinal paralysis (2), Duchenne-Aran muscular atrophy (2) and progressive spinal muscular atrophy (1).

  • ALS, amyotrophic lateral sclerosis; BPH, benign prostatic hyperplasia; ICD-8, International Classification of Diseases, 8th edition; ICD-10, International Classification of Diseases, 10th edition; MND, motor neuron disease.