Table 2

Concordance results for parent–child associations for relative telomere length

Relationship pairingPearson’s correlationLinear regression
nCoefficient
(95% CI)
Coefficient*
(95% CI)
P valueP value for interaction†P trend‡
Parent–child11430.24 (0.19 to 0.30)0.36 (0.28 to 0.45)<0.001
 By parent age tertile§
  Parent–child0.2
   Youngest3490.32 (0.22 to 0.41)0.49 (0.34 to 0.64)<0.0010.04
   Middle3830.25 (0.15 to 0.34)0.35 (0.21 to 0.48)<0.001
   Oldest4110.17 (0.07 to 0.26)0.26 (0.11 to 0.41)0.001
  Father–child0.04
   Youngest270.57 (0.24 to 0.78)0.83 (0.26 to 1.40)0.0060.01
   Middle500.34 (0.07 to 0.56)0.48 (0.10 to 0.87)0.02
   Oldest660.18 (−0.07 to 0.40)0.18 (−0.09 to 0.45)0.2-
  Mother–child0.5
   Youngest3220.28 (0.18 to 0.38)0.43 (0.27 to 0.58)<0.0010.2
   Middle3330.23 (0.12 to 0.33)0.32 (0.17 to 0.47)<0.001
   Oldest3450.17 (0.07 to 0.27)0.28 (0.11 to 0.46)0.002
Sex-specific
 Father–child1430.34 (0.18 to 0.48)0.45 (0.24 to 0.67)<0.001
   Father–son780.37 (0.16 to 0.55)0.48 (0.21 to 0.76)0.001
   Father–daughter650.26 (0.02 to 0.47)0.38 (0.01 to 0.76)0.05
 Mother–child10000.22 (0.17 to 0.28)0.34 (0.25 to 0.43)<0.001
   Mother–son4730.19 (0.10 to 0.27)0.27 (0.14 to 0.39)<0.001
   Mother–daughter5270.26 (0.17 to 0.33)0.40 (0.27 to 0.53)<0.001
  • *The estimated linear regression coefficient represents the change in childrens’ T/S ratio for every one unit higher T/S ratio for parents.

  • †P-interaction is the p-value for the interaction term between parent age and parent telomere length in the linear regression model with parent sex (if applicable) and child sex included.

  • ‡P-trend is the p-value for the interaction term between parent age tertile variable and parent telomere length in the linear regression model with parent sex (if applicable) and child sex included.

  • §Youngest, middle and oldest parent tertiles aged 28–41, 42–45 and 46–71 years, respectively.

  • n, sample size number.