Table 2

Medication adherences according to age and numbers of medications

ARB-only group
(n=29 400)
CCB-only group
(n=58 401)
MPC group
(n=10 458)
SPC group
(n=18 418)
p value* MPR differences P value
Crude
MPR mean
Adjusted
MPR mean§(95% CI)
Crude
MPR mean
Adjusted
MPR mean§(95% CI)
Crude
MPR mean
Adjusted
MPR mean§ (95% CI)
Crude
MPR mean
Adjusted
MPR mean§ (95% CI)
81.081.6 (81.3 to 81.9)80.979.7 (79.5 to 79.9)85.387.2 (86.7 to 87.7)87.789.7 (89.3 to 90.0)<0.012.5<0.01
Age group, years (n=116 677)
 20–49 (n=24 957)77.677.9 (77.3 to 78.4)77.476.1 (75.5 to 76.7)83.184.9 (83.7 to 86.0)83.785.1 (84.4 to 85.8)<0.010.20.20
 50–64 (n=46 085)82.683.0 (82.6 to 83.4)82.981.9 (81.5 to 82.2)86.488.0 (87.2 to 88.8)89.390.8 (90.3 to 91.4)<0.012.8<0.01
 65–74 (n=30 652)82.483.0 (82.5 to 83.5)82.381.4 (81.0 to 81.8)86.588.1 (87.1 to 89.0)90.692.3 (91.5 to 93.0)<0.014.2<0.01
 ≥75 (n=14 983)79.380.1 (79.3 to 81.0)77.476.6 (76.0 to 77.1)83.384.8 (83.3 to 86.3)87.589.3 (88.0 to 90.7)<0.014.5<0.01
Average no. of medications
 1–2 (n=19 523)79.680.3 (79.6 to 80.9)79.478.1 (77.4 to 78.7)85.887.6 (85.2 to 90.0)85.987.9 (87.0 to 88.9)<0.010.30.68
 3–4 (n=48 388)81.382.0 (81.6 to 82.5)81.680.6 (80.2 to 80.9)87.388.7 (87.9 to 89.4)87.489.2 (88.7 to 89.8)<0.010.60.99
 5–6 (n=30 105)81.982.3 (81.9 to 82.8)81.480.5 (80.1 to 80.9)86.487.5 (86.7 to 88.4)89.390.6 (89.9 to 91.3)<0.013.1<0.01
 7–9 (n=13 071)81.481.6 (80.9 to 82.3)80.478.9 (78.2 to 79.6)82.885.3 (84.1 to 86.5)88.890.9 (89.8 to 92.0)<0.015.6<0.01
 ≥9 (n=5590)78.377.9 (76.8 to 79.0)78.376.3 (75.2 to 77.4)78.382.5 (80.6 to 84.4)88.891.2 (89.3 to 93.1)<0.018.7<0.01
  • Analyses were performed using ANCOVA.

  • *P value of crude MPR mean.

  • †MPR differences=adjusted MPR of SPC group – adjusted MPR of MPC group.

  • ‡P value of MPR differences.

  • §Adjusted for factors associated with the patient (age, sex), condition (comorbidity), therapy (drug costs, number of concurrent drugs, prescription period), the healthcare system (insurance coverage) and the social/economic status (income, residence).

  • ANCOVA, analysis of covariance; ARB, angiotensin II receptor blockers; CCB, calcium channel blockers; MPC, multiple-pill combination; MPR, medication possession ratio; SPC, single-pill combination