Table 5

Analysis of mediation in the association between maternal smoking during pregnancy and body composition measures at adulthood in the 1982 (at 30 years) and 1993 (22 years) Pelotas birth cohorts, Brazil

Anthropometric and body composition measuresMediatorsG-computation estimate (95% CI)Mediated effect (%)
Natural direct effectNatural indirect effect
Body mass index (kg/m2)Birth weight0.79 (0.44 to 1.15)0.13 (−0.05 to 0.31)14.1
Weight gain from birth to 2 years0.01 (−0.53 to 0.54)0.21 (−0.08 to 0.50)96.2
Fat mass index (kg/m2)Birth weight0.44 (0.19 to 0.70)−0.03 (−0.16 to 0.10)7.7
Weight gain from birth to 2 years−0.02 (−0.40 to 0.35)−0.06 (−0.27 to 0.14)71.7
Android to gynoid fat ratioBirth weight0.014 (0.006 to 0.022)−0.002 (−0.006 to 0.002)17.1
Weight gain from birth to 2 years0.018 (0.005 to 0.030)0.001 (−0.006 to 0.007)3.4
Waist circumference (cm)Birth weight2.02 (1.28 to 2.76)0.18 (−0.22 to 0.57)8.1
Weight gain from birth to 2 years0.12 (−1.03 to 1.26)0.72 (0.09 to 1.34)86.1
Waist to height ratioBirth weight0.012 (0.007 to 0.016)0.001 (−0.002 to 0.003)3.0
Weight gain from birth to 2 years0.002 (−0.005 to 0.009)0.003 (−0.001 to 0.007)56.0
Lean mass index (kg/m2)Birth weight0.37 (0.25 to 0.48)0.04 (−0.02 to 0.10)8.9
Weight gain from birth to 2 years0.16 (−0.02 to 0.34)−0.02 (−0.11 to 0.08)12.7
Height (cm)Birth weight−0.40 (−0.78 to −0.02)−0.18 (−0.39 to 0.03)30.9
Weight gain from birth to 2 years−0.93 (−1.52 to −0.33)0.10 (−0.24 to 0.43)11.5