IHD | CVD | ASCVD | ||||
Variables and categories | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value |
Age (5-year age group) | 1.4 (1.2 to 1.6) | <0.0001 | 1.4 (1.3 to 1.6) | <0.0001 | 1.3 (1.2 to 1.4) | <0.0001 |
Cigarette smoking | ||||||
Ex-smoker | 1.0 (0.9 to 1.2) | 0.8567 | 1.1 (0.9 to 1.3) | 0.5008 | 1.1 (1.0 to 1.2) | 0.1406 |
Current smoker | 1.5 (1.3 to 1.6) | <0.0001 | 1.4 (1.2 to 1.6) | <0.0001 | 1.4 (1.3 to 1.5) | <0.0001 |
Blood pressure† | ||||||
High normal | 1.2 (1.1 to 1.4) | <0.0001 | 1.2 (1.0 to 1.3) | 0.0152 | 1.2 (1.1 to 1.3) | <0.0001 |
Stage 1 hypertension | 1.6 (1.4 to 1.8) | <0.0001 | 1.7 (1.5 to 2.0) | <0.0001 | 1.7 (1.5 to 1.8) | <0.0001 |
Stage 2 hypertension | 2.0 (1.6 to 2.5) | <0.0001 | 3.2 (2.5 to 4.0) | <0.0001 | 2.9 (2.5 to 3.3) | <0.0001 |
Total cholesterol‡ | ||||||
Borderline-high cholesterol | 1.4 (1.3 to 1.6) | <0.0001 | 1.4 (1.3 to 1.6) | <0.0001 | 1.4 (1.3 to 1.5) | <0.0001 |
High cholesterol | 2.5 (2.1 to 2.8) | <0.0001 | 1.7 (1.4 to 2.1) | <0.0001 | 2.1 (1.8 to 2.3) | <0.0001 |
Fasting blood sugar§ | ||||||
Diabetes | 1.3 (0.9 to 1.9) | 0.1375 | 1.6 (1.1 to 2.3) | 0.0222 | 1.5 (1.2 to 1.9) | 0.0008 |
Physical activity | ||||||
No exercise | 1.1 (1.0 to 1.3) | 0.0122 | 1.1 (1.0 to 1.3) | 0.2156 | 1.1 (1.0 to 1.3) | 0.0075 |
*HRs and 95% Cls from multivariable Cox proportional hazards models.
†The reference category is normal (systolic blood pressure <140 mm Hg and diastolic blood pressure <90 mm Hg).
‡The reference category is desirable (serum cholesterol level, <5.17 mmol/L [200 mg/dL]).
§The reference category is a fasting serum glucose level of less than 6.99 mmol/L (126 mg/dL).