Table 3

Raine Study measurements on the Generation 1 cohort

Follow-upMeasurements
18 weeks pregnancyMother questionnaire: age, ethnicity, religion, education, normal weight, info about own birth, diet, left/right handed, marital status, income, house and environment, pets, occupation and employment, activity, life stress, smoking, alcohol, caffeine, non-prescription drugs, substance exposure, medical history, social support, information about father: age, ethnicity, diet, left/right handed, smoking, drugs, medical history.
Father questionnaire: self-reported height and weight, birth information, education, occupation, toxin exposure.
Mother clinical assessment: weight, height, head circumference, fetal continuous-wave Doppler scans and ultrasound imaging scans.
Mother blood sample: vitamin D.
Father clinical assessment: head circumference (measured by mother).
34 weeks pregnancyMother questionnaire: caffeine, alcohol, smoking, medicines, non-prescription (recreational) drugs, life stress, toxin exposure.
Mother clinical assessment: weight, fetal continuous-wave Doppler scans and ultrasound imaging scans.
BirthMother antenatal information from maternal medical records, including: anaemia, diabetes, hypertension, post-partum complications, labour details, placental weight and shape, fetal continuous-wave Doppler scans and ultrasound imaging scans, postnatal blues (3 days after birth).
Mother blood sample: phthalates, BPA, androgen levels.
Year 1 follow-upMother questionnaire: home details, family structure, social benefits, occupation and employment, income, smoking, pets, life stress, breast feeding, information about father: occupation and employment.
Year 2
follow-up
Mother questionnaire: home details, family structure, social benefits, occupation and employment, income, smoking, pets, life stress, breast feeding, social support, information about father: occupation and employment.
Year 3
follow-up
Mother questionnaire: home details, family structure, social benefits, occupation and employment, income, smoking, pets, life stress, breast feeding, family functioning, happiness, self-efficacy, information about father: occupation and employment, happiness.
Year 5
follow-up
Mother questionnaire: home details, family structure, social benefits, occupation and employment, income, smoking, asthma, allergies, pets, life stress, family functioning, happiness, information about father: occupation and employment, asthma, allergies, happiness.
Mother clinical assessment: blood pressure, weight, height.
Father clinical assessment: blood pressure, weight, height.
Year 8
follow-up
Primary caregiver questionnaire: home details, family structure, social benefits, occupation and employment, income, smoking, medical history, asthma, allergies, pets, general health, mental health, life stress, education, happiness, family functioning, information about secondary caregiver: occupation and employment, medical history, asthma, allergies, general health, mental health, education, happiness.
Mother clinical assessment: weight, height, blood pressure.
Mother blood sample: haemoglobin, blood glucose, cholesterol, triglycerides, HDL, LDL, iron, transferrin, ferritin.
Father clinical assessment: weight, height, blood pressure.
Father blood sample: haemoglobin, blood glucose, cholesterol, triglycerides, HDL, LDL, iron, transferrin, ferritin.
Year 14
follow-up
Primary caregiver questionnaire: home details, family structure, social benefits, occupation and employment, income, neighbourhood, smoking, general health, mental health, alcohol, back pain, physical activity, motivation for physical activity, self-reported weight, diet, depression, anxiety, life stress, relationships, happiness, family functioning, social support, medical history, pets.
Secondary caregiver questionnaire: social benefits, occupation and employment, income, neighbourhood, smoking, general health, mental health, alcohol, back pain, physical activity, self-reported weight, diet.
Mother clinical assessment: height, weight, blood pressure, medications.
Mother blood sample: DNA, blood glucose, cholesterol, triglycerides, HDL, LDL, insulin.
Father clinical assessment: height, weight, blood pressure, medications.
Father blood sample: DNA, blood glucose, cholesterol, triglycerides, HDL, LDL, insulin.
Year 17
follow-up
Primary caregiver questionnaire: home details, family structure, social benefits, occupation and employment, income, neighbourhood, general health, mental health, smoking, alcohol, physical activity, back pain, motivation for physical activity, screen time, diet, self-reported weight, life stress, depression, anxiety, relationships, happiness, family functioning, social support, self-efficacy, social support, pets, asthma, allergies, medical history.
Secondary caregiver questionnaire: family structure, social benefits, occupation and employment, income, neighbourhood, general health, mental health, smoking, alcohol, physical activity, back pain, motivation for physical activity, screen time, diet, self-reported weight.
Mother clinical assessment: weight, height, blood pressure, medications.
Mother blood sample: DNA, blood glucose, cholesterol, triglycerides, HDL, LDL.
Father clinical assessment: weight, height, blood pressure, medications.
Father blood sample: DNA, blood glucose, cholesterol, triglycerides, HDL, LDL.
Year 26
follow-up
Mother questionnaire: home details, family structure, social benefits, occupation and employment, income, education, exercise, general health, medical history, life stress, depression, anxiety, sun exposure, physical activity, weight, screen time, smoking, alcohol, drugs, asthma, allergies, pain, menopause, diet, sleep, driving, restless legs, memory.
Father questionnaire: home details, family structure, social benefits, occupation and employment, income, education, exercise, general health, medical history, life stress, depression, anxiety, sun exposure, physical activity, weight, screen time, smoking, alcohol, drugs, asthma, allergies, pain, diet, sleep, driving, restless legs, memory.
Mothers clinical assessment: height, weight, waist, hip, neck circumference, blood pressure, heart rate, moles, sensory perception, three-dimensional (3D) photo head, body composition, lung function, vision, eye health, urine (microalbuminuria, sodium, potassium levels), cognition, sleep (PSG), physical activity (actigraphy).
Mother blood sample: DNA, full blood cell count, haemoglobin, glucose, cholesterol, iron, insulin.
Father clinical assessment: height, weight, waist, hip, neck circumference, blood pressure, heart rate, moles, sensory perception, 3D photo head, body composition, lung function, vision, eye health, urine (microalbuminuria, sodium, potassium levels), cognition, sleep (PSG), physical activity (actigraphy).
Father blood sample: DNA, full blood cell count, haemoglobin, glucose, cholesterol, iron, insulin.
  • HDL, high-density lipoprotein; LDL, low-density lipoprotein; PSG, polysomnography.