Sources of historical information
| Treatment effect; HR (95% CI) | |
| INT-0133 trial14
(n=662) | 0.80 (0.62 to 1.00) |
| INT-0133 trial15
(n=91) | 0.72 (0.42 to 1.20) |
| Overall HR estimated from the fixed-effect meta-analysis | 0.786 (SE=0.110) (no heterogeneity across trial) |
| Individual control arm (See figure 2) | |
| Sarcome-09/OS2006 subgroup matching the following criteria: Patients <31 years old Metastatic disease at diagnosis or non-responders to chemotherapy No event during the preoperative chemotherapy Patients with surgery Chemotherapy with methotrexate Included in the control arm of the OS2006 randomised trial (256 patients, 116 events) | |