Table 3

Rates and RRs for falls and fractures estimated over the study period in OAB cohort 2 and in the non-OAB cohort, according to baseline anticholinergic burden; Truven MarketScan databases 2007–2015

OAB cohort 2Non-OAB cohortOAB versus non-OAB RRs
n=43 483n=86 966n=130 449
Fall and fracture rates (95% CI) per 100 person-years
Overall, crude rate4.8 (4.7 to 5.0)3.5 (3.5, to 3.6)1.4 (1.3 to 1.5)
By baseline anticholinergic burden level*
 No burden (0)3.1 (2.9 to 3.3)2.7 (2.6 to 2.8)1.2 (1.1 to 1.3)
 Low (1–89)4.3 (4.0 to 4.6)3.8 (3.6 to 4.0)1.1 (1.0 to 1.2)
 Medium (90–499)5.5 (5.2 to 5.8)5.1 (4.9 to 5.4)1.1 (1.0 to 1.2)
 High (500+)6.9 (6.6 to 7.3)8.1 (7.4 to 8.8)0.9 (0.8 to 0.9)
RRs, by anticholinergic burden level
Any burden versus no burden1.8 (1.7 to 1.9)1.8 (1.7 to 1.9)
  Low burden versus no burden1.4 (1.3 to 1.5)1.4 (1.3 to 1.5)
  Medium burden versus no burden1.7 (1.6 to 1.9)1.9 (1.8 to 2.0)
  High burden versus no burden2.2 (2.0 to 2.4)3.0 (2.7 to 3.3)
  • *Baseline anticholinergic burden assessed over the 12-vmonth pre-index period.

  • OAB, overactive bladder; RR, rate ratio.