Knee brand, bearing and constraint | Number at risk | Cumulative failure (%) | Difference in failure (%) | 95% CI | Equivalence status | P value |
(TKR) NexGen cemented, unconstrained fixed | 8639 | 1.76 | (Reference) | |||
(TKR) AGC cemented, unconstrained fixed | 16 871 | 2.28 | 0.52 | (0.24 to 0.80) | Non-inferiority not shown | <0.001 |
(TKR) AGC hybrid, unconstrained fixed | 369 | 2.59 | 0.83 | (−0.70 to 2.36) | Non-inferiority not shown | 0.143 |
(TKR) AGC uncemented, unconstrained fixed | 468 | 4.87 | 3.11 | (1.33 to 4.88) | Inferior by ≥20% | <0.001 |
(TKR) Advance MP cemented, unconstrained fixed | 1725 | 3.18 | 1.42 | (0.74 to 2.11) | Inferior by ≥20% | <0.001 |
(TKR) Advance PS cemented, posterior-stabilised fixed | 266 | 3.48 | 1.72 | (−0.11 to 3.55) | Non-inferiority not shown | 0.033 |
(TKR) Columbus cemented, unconstrained fixed | 1224 | 2.49 | 0.73 | (0.08 to 1.38) | Non-inferiority not shown | 0.013 |
(TKR) E-Motion Bicondylar Knee uncemented, unconstrained mobile | 519 | 2.49 | 0.73 | (−0.41 to 1.88) | Non-inferiority not shown | 0.105 |
(TKR) FS cemented, unconstrained fixed | 305 | 1.76 | 0.00 | (−1.41 to 1.40) | Non-inferiority not shown | 0.497 |
(TKR) Genesis 2 cemented, posterior-stabilised fixed | 1723 | 2.97 | 1.21 | (0.61 to 1.82) | Inferior by ≥20% | <0.001 |
(TKR) Genesis 2 cemented, unconstrained fixed | 6545 | 2.17 | 0.41 | (0.08 to 0.74) | Non-inferiority not shown | 0.008 |
(TKR) Genesis 2 cemented, unconstrained mobile | 310 | 3.52 | 1.76 | (−0.13 to 3.65) | Non-inferiority not shown | 0.034 |
(TKR) Genesis 2 Oxinium cemented, posterior-stabilised fixed | 411 | 5.27 | 3.51 | (1.89 to 5.13) | Inferior by ≥100% | <0.001 |
(TKR) Genesis 2 Oxinium cemented, unconstrained fixed | 1175 | 3.42 | 1.65 | (0.76 to 2.55) | Inferior by ≥20% | <0.001 |
(TKR) Insall-Burstein 2 cemented, posterior-stabilised fixed | 892 | 2.88 | 1.12 | (0.06 to 2.17) | Non-inferiority not shown | 0.019 |
(TKR) Kinemax cemented, unconstrained fixed | 3927 | 3.08 | 1.32 | (0.76 to 1.87) | Inferior by ≥20% | <0.001 |
(TKR) LCS Complete cemented, unconstrained mobile | 2774 | 2.88 | 1.12 | (0.54 to 1.70) | Inferior by ≥20% | <0.001 |
(TKR) LCS Complete uncemented, unconstrained mobile | 3472 | 2.36 | 0.60 | (0.14 to 1.06) | Non-inferiority not shown | 0.005 |
(TKR) LCS uncemented, unconstrained mobile | 485 | 2.82 | 1.06 | (−0.36 to 2.48) | Non-inferiority not shown | 0.072 |
(TKR) MRK cemented, unconstrained fixed | 1681 | 2.07 | 0.31 | (−0.26 to 0.87) | Non-inferiority not shown | 0.143 |
(TKR) Maxim cemented, unconstrained fixed | 481 | 1.86 | 0.10 | (−1.06 to 1.25) | Non-inferiority not shown | 0.436 |
(TKR) NRG cemented, posterior-stabilised fixed | 1291 | 2.62 | 0.86 | (0.10 to 1.62) | Non-inferiority not shown | 0.014 |
(TKR) NRG cemented, unconstrained fixed | 1649 | 3.14 | 1.38 | (0.67 to 2.09) | Inferior by ≥20% | <0.001 |
(TKR) Natural Knee II cemented, unconstrained fixed | 767 | 2.02 | 0.26 | (−0.65 to 1.16) | Non-inferiority not shown | 0.288 |
(TKR) NexGen cemented, posterior-stabilised mobile | 267 | 3.93 | 2.17 | (0.20 to 4.14) | Non-inferiority not shown | 0.016 |
(TKR) NexGen cemented, posterior-stabilised fixed | 11 354 | 2.89 | 1.13 | (0.81 to 1.45) | Inferior by ≥20% | <0.001 |
(TKR) NexGen hybrid, unconstrained fixed | 379 | 1.47 | −0.29 | (−1.39 to 0.81) | Non-inferiority not shown | 0.303 |
(TKR) NexGen uncemented, posterior-stabilised fixed | 568 | 1.81 | 0.05 | (−0.87 to 0.97) | Non-inferiority not shown | 0.456 |
(TKR) NexGen uncemented, unconstrained fixed | 1639 | 3.13 | 1.36 | (0.59 to 2.14) | Inferior by ≥20% | <0.001 |
(TKR) Optetrak cemented, posterior-stabilised fixed | 533 | 3.51 | 1.75 | (0.29 to 3.20) | Non-inferiority not shown | 0.009 |
(TKR) PFC Sigma Bicondylar Knee cemented, posterior-stabilised mobile | 1976 | 2.65 | 0.89 | (0.27 to 1.51) | Non-inferiority not shown | 0.002 |
(TKR) PFC Sigma Bicondylar Knee cemented, posterior-stabilised fixed | 15 828 | 2.16 | 0.40 | (0.13 to 0.67) | Non-inferiority not shown | 0.002 |
(TKR) PFC Sigma Bicondylar Knee cemented, unconstrained fixed | 36 856 | 1.83 | 0.07 | (−0.16 to 0.30) | Non-inferior | 0.279 |
(TKR) PFC Sigma Bicondylar Knee cemented, unconstrained mobile | 2565 | 2.75 | 0.98 | (0.40 to 1.57) | Inferior by ≥20% | 0.001 |
(TKR) PFC Sigma Bicondylar Knee hybrid, unconstrained fixed | 619 | 1.86 | 0.10 | (−0.93 to 1.12) | Non-inferiority not shown | 0.428 |
(TKR) PFC Sigma Bicondylar Knee monobloc polyethylene tibia | 898 | 1.69 | −0.07 | (−0.61 to 0.46) | Non-inferiority not shown | 0.394 |
(TKR) Profix cemented, unconstrained fixed | 360 | 3.97 | 2.21 | (0.29 to 4.12) | Non-inferiority not shown | 0.012 |
(TKR) Profix uncemented, unconstrained fixed | 856 | 1.21 | −0.55 | (−1.26 to 0.16) | Non-inferior | 0.064 |
(TKR) Rotaglide+ cemented, unconstrained mobile | 610 | 4.40 | 2.64 | (1.11 to 4.17) | Inferior by ≥20% | <0.001 |
(TKR) Rotaglide cemented, unconstrained mobile | 291 | 4.30 | 2.54 | (0.62 to 4.45) | Inferior by ≥20% | 0.005 |
(TKR) Scorpio cemented, posterior-stabilised mobile | 517 | 2.39 | 0.63 | (−0.62 to 1.89) | Non-inferiority not shown | 0.162 |
(TKR) Scorpio cemented, posterior-stabilised fixed | 2090 | 2.91 | 1.14 | (0.43 to 1.86) | Inferior by ≥20% | 0.001 |
(TKR) Scorpio cemented, unconstrained fixed | 3667 | 3.06 | 1.30 | (0.75 to 1.86) | Inferior by ≥20% | <0.001 |
(TKR) Scorpio cemented, unconstrained mobile | 436 | 3.94 | 2.18 | (0.43 to 3.93) | Inferior by ≥20% | 0.007 |
(TKR) Scorpio hybrid, unconstrained fixed | 374 | 3.33 | 1.57 | (−0.16 to 3.30) | Non-inferiority not shown | 0.038 |
(TKR) Scorpio uncemented, unconstrained fixed | 1440 | 2.50 | 0.74 | (−0.04 to 1.51) | Non-inferiority not shown | 0.031 |
(TKR) TC Plus cemented, unconstrained fixed | 3133 | 3.00 | 1.23 | (0.64 to 1.83) | Inferior by ≥20% | <0.001 |
(TKR) TC Plus cemented, unconstrained mobile | 1758 | 2.61 | 0.84 | (0.13 to 1.56) | Non-inferiority not shown | 0.010 |
(TKR) TC Plus uncemented, unconstrained mobile | 434 | 1.80 | 0.04 | (−1.00 to 1.07) | Non-inferiority not shown | 0.473 |
(TKR) Triathlon cemented, posterior-stabilised fixed | 1851 | 2.53 | 0.77 | (0.23 to 1.31) | Non-inferiority not shown | 0.003 |
(TKR) Triathlon cemented, unconstrained fixed | 5995 | 1.94 | 0.18 | (−0.13 to 0.48) | Non-inferiority not shown | 0.126 |
(TKR) Vanguard cemented, posterior-stabilised fixed | 471 | 2.57 | 0.81 | (−0.05 to 1.67) | Non-inferiority not shown | 0.033 |
(TKR) Vanguard cemented, unconstrained fixed | 3489 | 2.10 | 0.34 | (−0.01 to 0.70) | Non-inferiority not shown | 0.028 |
(UNI) AMC/Uniglide Unicondylar, fixed | 348 | 3.97 | 2.21 | (0.51 to 3.90) | Inferior by ≥20% | 0.005 |
(UNI) AMC/Uniglide Unicondylar, mobile | 519 | 8.90 | 7.14 | (5.06 to 9.22) | Inferior by ≥100% | <0.001 |
(UNI) MG Uni Unicondylar, fixed | 1130 | 5.36 | 3.60 | (2.33 to 4.86) | Inferior by ≥100% | <0.001 |
(UNI) Oxford Partial Knee Unicondylar, mobile | 14 581 | 5.72 | 3.96 | (3.59 to 4.33) | Inferior by ≥100% | <0.001 |
(UNI) Physica ZUK Unicondylar, fixed | 1280 | 3.88 | 2.12 | (1.35 to 2.89) | Inferior by ≥20% | <0.001 |
(UNI) Preservation Unicondylar, fixed | 566 | 8.55 | 6.79 | (4.61 to 8.96) | Inferior by ≥100% | <0.001 |
(UNI) Sigma HP Unicondylar, fixed | 948 | 4.36 | 2.59 | (1.75 to 3.44) | Inferior by ≥20% | <0.001 |
(UNI) Sled Unicondylar, fixed | 261 | 11.47 | 9.71 | (6.30 to 13.12) | Inferior by ≥100% | <0.001 |
TKR, total knee replacement; UNI, unicondylar knee replacement.