Table 2

HRs for dementia during the 6-year follow-up (2008–2013) according to body weight, socioeconomic status, health behaviours and cardiovascular risk factors at baseline among men

CasesUnivariable modelMultivariable model*
nHRs (95% CI)HRs (95% CI)
Body weight
 BMI change over 2 years †
  Decrease of >10%1771.45 (1.25 to 1.68)1.26 (1.08 to 1.46)
  Decrease of 5<−10%6621.28 (1.17 to 1.39)1.19 (1.09 to 1.29)
  Stable at ±5%3375Ref.Ref.
  Increase of 5<−10%4801.11 (1.01 to 1.22)1.02 (0.92 to 1.12)
  Increase of >10%1931.47 (1.27 to 1.69)1.25 (1.08 to 1.45)
 BMI
  <18.5 kg/m2 2391.54 (1.34 to 1.77)1.23 (1.07 to 1.42)
  18.5–23 kg/m2 20491.16 (1.08 to 1.24)1.06 (0.99 to 1.14)
  23–25 kg/m2 1293Ref.Ref.
  25–30 kg/m2 12570.98 (0.91 to 1.06)1.00 (0.93 to 1.08)
  ≥30 kg/m2 490.75 (0.56 to 1.00)0.76 (0.57 to 1.01)
Socioeconomic status
 Age48871.12 (1.11 to 0.00)1.11 (1.11 to 1.12)
 Income
  Low944Ref.Ref.
  Medium20121.01 (0.94 to 1.09)0.99 (0.92 to 1.07)
  High19311.04 (0.96 to 1.12)0.92 (0.85 to 0.99)
Health behaviours
 Smoking status
  Never smoked2678Ref.Ref.
  Past smoker7361.07 (0.99 to 1.16)1.07 (0.98 to 1.16)
  Current smoker14731.03 (0.96 to 1.09)1.10 (1.03 to 1.18)
 Drinking status
  None2333Ref.Ref.
  <2 times per week13750.85 (0.79 to 0.90)0.97 (0.91 to 1.04)
  ≥3 times per week11791.06 (0.99 to 1.14)1.11 (1.03 to 1.19)
 Physical activity
  None2961Ref.Ref.
  <2 times per week7960.73 (0.67 to 0.79)0.85 (0.78 to 0.92)
  ≥3 times per week11300.85 (0.79 to 0.91)0.89 (0.83 to 0.95)
Cardiovascular risk factors
 Total cholesterol
  Optimal2849Ref.Ref.
  Intermediate15150.97 (0.91 to 1.03)1.03 (0.96 to 1.09)
  High5230.89 (0.81 to 0.97)0.94 (0.86 to 1.04)
 Hypertension
  No2817Ref.Ref.
  Yes20701.29 (1.22 to 1.36)1.16 (1.09 to 1.24)
 Atrial fibrillation
  No4789Ref.Ref.
  Yes981.36 (1.11 to 1.66)1.05 (0.86 to 1.29)
 Congestive heart failure
  No4627Ref.Ref.
  Yes2601.46 (1.29 to 1.65)1.17 (1.02 to 1.33)
 DM diagnosis and FBS ‡
  No DM diagnosis and normal/pre-diabetic FBS3849Ref.Ref.
  No DM diagnosis and diabetic FBS3601.14 (1.02 to 1.27)1.14 (1.02 to 1.27)
  DM diagnosis and normal/pre-diabetic FBS4071.31 (1.19 to 1.45)1.25 (1.13 to 1.39)
  DM diagnosis and diabetic FBS2711.56 (1.38 to 1.76)1.59 (1.41 to 1.81)
  • *All variables were analysed in one model.

  • †The BMI change over 2 years was calculated as follows: (BMI at baseline−BMI in 2004 or 2005)/BMI at baseline.

  • ‡The combination of the physician’s diagnosis of DM using an International Classification of Diseases 10th Edition code (E10-E14) and the laboratory data of FBS of ≥126 mg/dL at baseline.

  • BMI, body mass index; DM, diabetes mellitus; FBS, fasting blood sugar.