Table 3

HRs for dementia during 6-year follow-up (2008–2013) according to body weight, socioeconomic status, health behaviours and cardiovascular risk factors at baseline among women

CasesUnivariable modelMultivariable model*
nHRs (95% CI)HRs (95% CI)
Body weight
 BMI change over 2 years †
  Decrease of >10%3251.33 (1.18 to 1.48)1.15 (1.03 to 1.29)
  Decrease of 5<−10%9431.16 (1.08 to 1.24)1.11 (1.03 to 1.19)
  Stable at ±5%4347Ref.Ref.
  Increase of 5<−10%7371.11 (1.03 to 1.20)1.07 (0.99 to 1.15)
  Increase of >10%3331.38 (1.23 to 1.54)1.17 (1.05 to 1.31)
 BMI
  <18.5 kg/m2 2031.26 (1.09 to 1.45)1.07 (0.92 to 1.24)
  18.5–23 kg/m2 22151.10 (1.03 to 1.17)1.05 (0.99 to 1.12)
  23–25 kg/m2 1672Ref.Ref.
  25–30 kg/m2 23380.98 (0.92 to 1.05)0.97 (0.91 to 1.03)
  ≥30 kg/m2 2570.99 (0.87 to 1.13)0.92 (0.81 to 1.05)
Socioeconomic status
 Age66851.10 (1.09 to 0.00)1.09 (1.08 to 1.10)
 Income
  Low1461Ref.Ref.
  Medium26580.91 (0.85 to 0.97)1.00 (0.94 to 1.06)
  High25660.87 (0.82 to 0.93)0.91 (0.85 to 0.97)
Health behaviours
 Smoking status
  Never smoked6357Ref.Ref.
  Past smoker661.21 (0.95 to 1.54)1.06 (0.83 to 1.36)
  Current smoker2621.38 (1.22 to 1.56)1.18 (1.04 to 1.34)
 Drinking status
  None6049Ref.Ref.
  <2 times per week5420.96 (0.88 to 1.05)1.00 (0.92 to 1.10)
  ≥3 times per week941.04 (0.85 to 1.27)0.95 (0.77 to 1.16)
 Physical activity
  None5064Ref.Ref.
  <2 times per week6720.77 (0.71 to 0.83)0.84 (0.77 to 0.91)
  ≥3 times per week9490.85 (0.79 to 0.91)0.92 (0.86 to 0.99)
Cardiovascular risk factors
 Total cholesterol
  Optimal2722Ref.Ref.
  Intermediate25540.99 (0.94 to 1.04)1.03 (0.97 to 1.08)
  High14091.02 (0.95 to 1.08)1.05 (0.98 to 1.12)
 Hypertension
  No3378Ref.Ref.
  Yes33071.37 (1.30 to 1.43)1.22 (1.16 to 1.28)
 Atrial fibrillation
  No6598Ref.Ref.
  Yes871.28 (1.04 to 1.59)0.96 (0.78 to 1.19)
 Congestive heart failure
  No6118Ref.Ref.
  Yes5671.44 (1.33 to 1.57)1.16 (1.06 to 1.27)
 DM diagnosis and FBS ‡
  No DM diagnosis and normal/pre-diabetic FBS5229Ref.Ref.
  No DM diagnosis and diabetic FBS3991.22 (1.11 to 1.36)1.13 (1.02 to 1.25)
  DM diagnosis and normal/pre-diabetic FBS6811.37 (1.27 to 1.49)1.29 (1.19 to 1.40)
  DM diagnosis and diabetic FBS3761.55 (1.40 to 1.73)1.47 (1.32 to 1.63)
  • *All variables were analysed in one model.

  • †The BMI change over 2 years was calculated as follows: (BMI at baseline−BMI in 2004 or 2005)/BMI at baseline.

  • ‡The combination of the physician’s diagnosis of DM using an International Classification of Diseases 10th Edition code (E10-E14) and the laboratory data of FBS of ≥126 mg/dL at baseline.

  • BMI, body mass index; DM, diabetes mellitus; FBS, fasting blood sugar.