Table 1

Trial process chart

	Baseline	Treatment phase			Follow-up phase
	Week	Week	Week	Week	Month	Month	Month
	–1	0	4	8	1	3	6
Patients
Enrollment	×
Signed informed consent		×
Medical history	×
Merger disease	×
Randomisation		×
Intervention			×	×
Primary outcomes
PSQI	×		×	×	×	×	×
Secondary outcomes
Actigraphy	×		×	×
HAMD	×		×	×	×	×	×
SAS	×		×	×
TESS			×	×	×	×	×
Drug dose record	×		×	×	×	×	×
Patients’ compliance			×	×	×	×	×

HAMD, Hamilton Rating Scale for Depression; PSQI, Pittsburgh Sleep Quality Index; SAS, Self-rating Anxiety Scale; TESS, Treatment Emergent Symptom Scale.