Child and maternal characteristics
| Risk factor | Data set 1: routine sampling Source | Data set 2: systematic sampling Source |
| Age of child at first urine sample (group 1/2 only) or index consultation (data set 2) | Datastore | EURICA and DUTY study data |
| Gender | WECC | EURICA and DUTY study data |
| Ethnicity | WECC | WECC and DUTY study data |
| Deprivation quintile at birth (taken from postcode at birth) | WDS: Welsh index of multiple deprivation and Townsend score | Townsend score; EURICA and DUTY study data |
| Maternal age at birth (years) (category) | WECC | EURICA and DUTY Welsh participants only: WECC |
| Birth weight (g) (category) | WECC | EURICA and DUTY Welsh participants only: WECC |
| Gestational age at birth (weeks) (category) | WECC | EURICA and DUTY Welsh participants only: WECC |
| Ever breast fed | WECC | EURICA and DUTY study data |
| Uropathogen (Enterobacteriaceae or other) (mcUTI only) | Datastore | EURICA and DUTY study data |
| Antimicrobial resistance (mcUTI only) | Datastore | EURICA and DUTY study data |
| Congenital malformations (con mals) | ||
| Known to be associatedwith UTI/renal scarring | PEDW | |
| 1. Spina bifida/neurobladder | NA: DUTY exclusion | |
| 2. Renal/urinary system con mals including vesicoureteric reflux (VUR) | EURICA and DUTY study data | |
| Possibly associatedwith UTI/renal scarring | ||
| 1. Down’s syndrome | PEDW; WECC | EURICA and DUTY study data |
| 2. Cerebral palsy/other paralytic syndromes | WECC | EURICA and DUTY study data |
| Congenital malformations—major/minor | WECC | EURICA and DUTY Welsh participants only: WECC |
| Comorbidities | ||
| 1. Diabetes diagnosed under the age of 5 years | PEDW | EURICA and DUTY study data* |
| 2. Renal or urogenital surgery | PEDW | EURICA study data* DUTY exclusion |
| 3. Cancer | PEDW | EURICA and DUTY study data* |
| 4. Immunosuppressive disease | PEDW | EURICA and DUTY study data* |
| 5. Circumcision (aged <5 years) | PEDW; GP | EURICA and DUTY study data* |
| Factors for follow-up of study participants and research question 2 | ||
| Symptoms and signs at index consultation | – | EURICA and DUTY study data |
| Management at index consultation | GP | EURICA and DUTY study data |
| Antenatal ultrasound urinary system abnormalities | – | EURICA and DUTY study data |
| Family history of UTI/urinary system problems | – | EURICA and DUTY study data |
| Recent antibiotics (7 days prior to index consultation) | GP | EURICA and DUTY* study data |
*At time of index consultation.
DUTY, Diagnosis of Urinary Tract infection in Young children; EURICA, Welsh cohort study of urinary tract infection in children; GP, general practice; mcUTI, microbiologically confirmed UTI; NA, not applicable; PEDW, Patient Episode Database for Wales; UTI, urinary tract infection; WDS, Welsh Demographic Service; WECC, Welsh Electronic Cohort of Children.