Table 2

BRIGHTLIGHT severity of illness index (see online supplemental file 3)

Cancer type11 Least severeIntermediate severityMost severe
Germ cell tumoursStages 1–3; stage unknown.Stage 4 (stage 1S=stage 4).
LeukaemiasCML.ALL; other and unspecified.AML.
Non-Hodgkin’s lymphoma and non-specified lymphomaOver 16 years, protocol unknown stage 1–2.Over 16 s, protocol unknown; stage 3–4; any paediatric-type protocol; all unknown.Burkitts (ICD-10 C83.7, morphology code 9687/3).
Hodgkin’s lymphomaAll stages.
Central nervous system tumoursPituitary adenomas (D35.2); subependymal giant cell astrocytoma (C43.2).Other completely resected WHO grade I tumours for which surgery is the only treatment needed, except craniopharyngiomas.Craniopharyngiomas; incompletely resected or unresectable grade I tumours; all grade II–IV tumours, any needing radiotherapy or chemotherapy. This includes ependymomas, medulloblastomas and intracranial GCTs.
Bone tumoursSurgery only (low grade, periosteal and parosteal).All other.
Soft tissue sarcomaStages 1–2.Stage 3; unknown.Stage 4.
RhabdomyosarcomaLow risk EpSSG A-D.All others; unknown.
MelanomaStages 1–2 (except 2c).Stage 2c; stage 3 (except 3c); stage unknown.Stage 3c; stage 4.
CarcinomaAll thyroid; all stage 1; Cervix stage unknown.Stages 2–3; all nasopharyngeal; stage unknown (except cervix).Stage 4.
Miscellaneous and unspecifiedAll.
  • ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; CML, chronic myeloid leukemia; EpSSG, European Paediatric Soft Tissue Sarcoma Study Group; GCT, germ cell tumours; ICD-10, International Classification of Diseases, 10th Revision.