Table 1

Literature on the impact of CPAP versus APAP on BP

Author (ref.)YearSample sizeStudy designDurationInterventionFindings
Bloch et al 44 2017208Randomised, parallel2 yearsAPAP (5–15 cmH2O) versus CPAP (90th percentile during titration)Reduction in MBP, SBP and DBP by 3–4 mm Hg (ITT) and 4–6 mm Hg (PPT), similar in APAPxCPAP*
Pépin et al 43 2016322Randomised, parallel4 monthsAPAP (minimal interval of 5 cmH2O) versus CPAP (95th percentile during titration)CPAP was more effective in reducing 24 hours DBP than APAP*†
Marrone et al 45 201117Randomised, parallel2 monthsAPAP (5–18 cmH2O) versus CPAP (fixed pressure determined during titration)Treatment reduced SBP during sleep and DBP during both sleep and wakefulness. Similar reductions in BP were demonstrated in both groups*
Patruno et al 42 200731Randomised, parallel3 monthsAPAP (4–15 cmH2O) versus CPAP (fixed pressure determined during titration)Significant reduction in SBP (from 144±10 to 132±8 mm Hg; p<0.001) and DBP (from 88±4 to 79±6 mm Hg; p<0.001) in the CPAP group but not in the APAP group (SBP, 142±12 to 136±6 mm Hg; DBP, 87.5±4 to 86±4 mm Hg)†
West et al 46 200698Randomised, parallel6 monthsAPAP versus APAP for 1 week and then CPAP (95th percentile during titration) or CPAP (determined by an algorithm)No difference between groups in MBP*
  • *Ambulatory blood pressure monitoring (24 hours).

  • †Office blood pressure measurements.

  • APAP, auto-adjusting positive airway pressure; BP, blood pressure; CPAP, continuous positive pressure; DBP, diastolic blood pressure; ITT, intention to treat; MBP, mean blood pressure; PPT, per-protocol analysis; SBP, systolic blood pressure.