Table 3

List of analytes tested for the HAPPI Kids study

BiochemicalImmunologicalHaematological
Sodium*†‡IgG*Factors: XII, XI, IX, X, II, VII, VIII, V
Potassium*†‡IgA*Inhibitors: protein C, protein S, antithrombin, alpha-2-macroglobulin
Chloride*†‡Ig M*Von Willebrand factor
Bicarbonate*†‡Rheumatoid factor*Collagen binding assay
Urea*†‡Complement component 3*Ristocetin cofactor assay
Creatinine*†‡Complement component 4*Activated partial thromboplastin time‡
Total bilirubin ‡Cystatin C*Prothrombin time‡
Conjugated bilirubin*†‡Anti-streptolysin O test*Fibrinogen‡
Alkaline phosphate*†‡Thyroid peroxidase*Thrombin clotting time
Aspartate aminotransferase *†‡Thyroglobulin*D-dimers‡
Alanine aminotransferase *†‡Iron*Full blood examination and reticulocytes
Gamma-glutamyl transferase *†‡Ferritin*‡Red cell folate
Total protein*†Transferrin*Glucose-6-phosphate dehydrogenase
Albumin*†Antinuclear antibodyActive B12
Calcium*†‡Soluble FAS ligandTotal homocysteine
Magnesium*†‡Soluble CD25Total B12
Phosphate*†‡IgESerum folate
Lactate dehydrogenase*†Classic haemolytic complement pathway
Creatine kinase *†Alternative haemolytic complement pathway
Lipase*†Mannose-binding lectin complement pathway
Amylase*†
Uric acid*†
Triglycerides *†
Cholesterol*†
High-density lipoprotein*†
Thyroid-stimulating hormone *†
Free thyroxine *†
Free triiodothyronine *†
Anti-Müllerian hormone*
Oestradiol*
Sex hormone-binding globulin*
Dehydroepiandrosterone—sulfate*
Cortisol*
Growth hormone*
Testosterone*
25-Hydroxyvitamin D*
High-sensitivity oestradiol*
Androstenedione*
17α-Hydroxyprogesterone*
Insulin-like growth factor 1*
Insulin-like growth factor-binding protein-3*

  • *Sample aliquots from the same patient are tested for the same analyte using different automated analysers in common clinical use to facilitate direct head-to-head comparison.

  • †Aliquots of the same sample are tested in different laboratories using the same analyser type and test method.

  • ‡Samples from preterm children are tested.

  • HAPPI Kids, Harmonising Age Pathology Parameters in Kids.