Table 2

Safety analyses of the vaccine

Adverse eventsNo of studiesInterventionControlRR (95% CI)Test for heterogeneity,%P value
n/N%n/N%
Systemic reaction
 Fever7375/268313.9124/122410.11.26 (1.03 to 1.53)I2=70.03
 Headache71015/268437.8408/122633.21.10 (1.01 to 1.20)I2=00.04
 Malaise7760/268428.3276/122622.51.18 (1.05 to 1.33)I2=00.005
Site reaction
 Pain7890/268433.1360/122629.31.06 (0.60 to 1.86)I2=950.85
 Erythema7198/26847.371/12265.70.95 (0.75 to 1.20)I2=00.68
 Oedema7158/26845.876/12266.10.72 (0.47 to 1.10)I2=460.13
 Serious adverse events91283/24 7685.2791/12.2506.40.84 (0.75 to 0.95)I2=200.006