Table 1

Eligibility criteria

Inclusion criteriaExclusion criteria
Age 18 years and aboveIs pregnant or breastfeeding
Is willing to undergo HIV testingHas extrapulmonary TB or drug-resistant TB
Has body weight between 30 kg and 65 kgHas body weight <30 kg or >65 kg
Patient has never received treatment with multidrug anti-TB therapy for more than a week.Has a prior history of exposure to anti-TB treatment for more than a week
Is willing to use an effective contraceptive method during the study periodHas a history of liver disease or current amino alanine transferase greater than three times the upper limit of normal (ULN) or total bilirubin concentration greater than 2.5 times the ULN
Is willing to attend a treatment centre for supervised treatment and remain within the study area limitIs serology positive for hepatitis B virus surface antigen or hepatitis C virus antibody
Is willing to sign the informed consent form and adhere to trial procedures and follow-upHas concomitant psychiatric illness or seizures
Consents for home visits by the study teamHas concomitant diabetes mellitus or random blood sugar >200 mg or fasting blood sugar >140 mg/dL
Has serum creatinine >1.2 mg/dL or blood urea >43 mg/dL