Table 4

Correlations change in ALT and changes in metabolic parameters

Variable Full CCI cohort
CCI cohort with abnormal baseline ALT levels
Unadjusted r P value*Adjusted r P value*Unadjusted r P value*Adjusted r P value*
Δ Body weight (%)0.1910.0430.1980.0040.2530.0560.2780.003
Δ Fasting glucose (mg/dL)0.1240.1180.1760.0040.1840.0510.3051.2×10–4
Δ HbA1c (%)0.1760.0430.1480.0330.2200.0180.2530.005
Δ Triglycerides (mg/dL)0.0320.7410.0250.4900.0910.4280.1060.163
Δ Cholesterol (mg/dL)−0.0760.375−0.0310.563−0.0460.663−0.0200.605
Δ HDL cholesterol (mg/dL)−0.1150.160−0.0690.219−0.1450.182−0.1180.207
Δ LDL cholesterol (mg/dL)−0.0490.526−0.0220.476−0.0420.669−0.0320.690
  • ΔMeans change from baseline.

  • *Unadjusted and adjusted Pearson’s correlations. Adjustments while controlling for individual baseline covariate levels, age, sex, race (African-American vs other), diabetes duration, body mass index and insulin use.

  • †ALT levels >19 in women and >30 in men.

  • ALT, alanine aminotransferase; CCI, continuous care intervention; HbA1c, glycosylated haemoglobin; HDL, high-density lipoprotein; LDL, low-density lipoprotein.