UCOD trends for decedents with Down syndrome, 2012–2016 US Multiple Cause-of-Death Mortality files (n=9114)
| ICD-10 chapter | Rank order change | Original UCOD (%) | Revised UCOD (%) | Absolute difference (%) | ||||
| X | J00-J99 | Diseases of the respiratory system | 3 | ↗ | 1 | 8.56 | 27.00 | 18.44 |
| IX | I00-I99 | Diseases of the circulatory system | 2 | → | 2 | 10.96 | 17.38 | 6.42 |
| VI | G00-G99 | Diseases of the nervous system | 4 | ↗ | 3 | 5.31 | 13.18 | 7.87 |
| V | F01-F99 | Mental, behavioural and neurodevelopmental disorders | 10 | ↗ | 4 | 1.73 | 11.82 | 10.09 |
| --- | --- | Unknown | 16 | ↗ | 5 | 0.00 | 5.65 | 5.65 |
| XX | V00-Y99 | External causes of mortality | 5 | ↘ | 6 | 2.79 | 3.86 | 1.07 |
| IV | E00-E89 | Endocrine, nutritional and metabolic diseases | 7 | → | 7 | 2.15 | 3.84 | 1.69 |
| XVIII | R00-R99 | Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | 15 | ↗ | 8 | 0.01 | 3.23 | 3.22 |
| I | A00-B99 | Certain infectious and parasitic diseases | 6 | ↘ | 9 | 2.32 | 3.12 | 0.80 |
| XIV | N00-N99 | Diseases of the genitourinary system | 11 | ↗ | 10 | 1.29 | 2.56 | 1.27 |
| XVII | Q00-Q99 | Congenital malformations, deformations and chromosomal abnormalities* | 1 | ↘ | 11 | 60.27 | 2.51 | −57.76 |
| XI | K00-K95 | Diseases of the digestive system | 9 | ↘ | 12 | 1.78 | 2.24 | 0.46 |
| II | C00-D49 | Neoplasms | 8 | ↘ | 13 | 2.10 | 2.12 | 0.02 |
| XIII | M00-M99 | Diseases of the musculoskeletal system and connective tissue | 12 | ↘ | 14 | 0.35 | 0.52 | 0.17 |
| III | D50-D89 | Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | 13 | ↘ | 15 | 0.26 | 0.49 | 0.23 |
| XII | L00-L99 | Diseases of the skin and subcutaneous tissue | 14 | ↘ | 16 | 0.11 | 0.46 | 0.35 |
| XVI | P00-P96 | Certain conditions originating in the perinatal period | 16 | ↘ | 17 | 0.00 | 0.02 | 0.02 |
| VIII | H60-H95 | Diseases of the ear and mastoid process | 15 | ↘ | 18 | 0.01 | 0.01 | 0.00 |
↵*Indicates ICD-10 chapter inclusive of Down syndrome.
ICD-10, International Statistical Classification of Diseases and Related Health Problems, Tenth Revision; UCOD, underlying cause of death.