Table 1

Inclusion and exclusion criteria specific to primary and secondary objectives

Inclusion criteriaExclusion criteria
Primary objective

  •  Participants aged 18 years and over

✓Cannot be ascertained whether bleed occurred in-hospital or postdischarge

  •  Participants discharged with an ACS diagnosis (UA or STEMI or NSTEMI) at index hospitalisation

✓In-hospital bleeds only

  •  Randomised controlled trial or observational study

✓Incidence and 95% CI or number of bleeding events cannot be extracted or calculated

  •  Bleeding occurred after hospital discharge

✓Study population combined patients with ACS and other coronary diseases such as stable angina

  •  Any type of bleeding examined (such as gastrointestinal bleed) post hospital discharge for ACS

✓Postdischarge bleeding after PCI, without specifying the clinical presentation for the PCI or whether the PCI was elective

  •  Incidence and associated 95% CI can be extracted or calculated

✓Only reporting CABG-related bleeds
✓Conference/study abstracts, editorials and reviews
Secondary objective

  •  Participants aged 18 years and over

✓Cannot be ascertained whether bleed occurred in-hospital or postdischarge

  •  Participants discharged with an ACS diagnosis (UA or STEMI or NSTEMI) at index hospitalisation

✓In-hospital bleeds only

  •  Randomised controlled trial or observational study

✓Study population combined patients with ACS and other coronary diseases such as stable angina

  •  Bleeding occurred after hospital discharge

✓Postdischarge bleeding after PCI, without specifying the clinical presentation for the PCI or whether the PCI was elective

  •  Evaluated outcome of or composite of mortality, MI, rehospitalisation and MACE in bleed vs no bleed cohorts

✓Only reporting CABG-related bleeds
✓Conference/study abstracts, editorials and reviews

  • ACS, acute coronary syndrome; CABG, coronary artery bypass graft; MACE, major adverse cardiovascular event; MI, myocardial infarction; NSTEMI, non-ST-elevation myocardial infarction; PCI, percutaneous coronary intervention; STEMI, ST-elevation myocardial infarction; UA, unstable angina.