Variable | PLR ≤150 (n=1780) | 150<PLR≤250 (n=1380) | PLR >250 (n=2377) | P value |
Age (years) | 63.0±16.6 | 65.0±16.6 | 66.1±15.5 | <0.001 |
Gender (male), n (%) | 805 (45.2) | 590 (42.7) | 1096 (46.1) | 0.133 |
BMI (kg/m2) | 30.8±8.9 | 34.1±13.5 | 35.2±39.5 | 0.001 |
Ethnicity, n (%) | ||||
White | 1202 (67.5) | 987 (71.5) | 1761 (74.0) | 0.754 |
Black | 180 (10.1) | 101 (7.3) | 146 (6.1) | <0.001 |
Asian | 39 (2.2) | 30 (2.1) | 71 (2.9) | 0.169 |
Emergency | 1641 (92.1) | 1284 (93.0) | 2229 (93.7) | 0.138 |
ICU type, n (%) | ||||
MICU | 953 (53.5) | 727 (52.6) | 1362 (57.2) | 0.008 |
CCU/CSRU | 413 (23.2) | 323 (23.4) | 453 (19.0) | 0.001 |
TSICU/SICU | 414 (23.2) | 330 (23.9) | 562 (23.6) | 0.908 |
Vasopressors, n (%) | ||||
Norepinephrine | 566 (31.7) | 374 (27.1) | 711 (29.9) | 0.016 |
Dopamine | 198 (11.1) | 151 (10.9) | 256 (10.7) | 0.013 |
Epinephrine | 67 (3.7) | 28 (2.0) | 37 (1.5) | <0.001 |
Vasopressin | 156 (8.7) | 88 (6.3) | 172 (7.2) | 0.033 |
Overall vasopressor use | 701 (39.3) | 482 (34.9) | 858 (36.1) | 0.022 |
Fluid input/output (mL/kg/48 hours) | ||||
Fluid intake | 99.9±60.9 | 90.7±57.6 | 97.2±61.2 | <0.001 |
Urine output | 42.0±32.0 | 42.9±30.3 | 41.9±29.5 | 0.5659 |
Fluid balance | 46.7±59.4 | 38.3±55.1 | 46.0±60.4 | <0.001 |
Infection site, n (%) | ||||
Respiratory infection | 1048 (58.8) | 929 (67.3) | 1580 (66.4) | <0.001 |
Blood infection | 768 (43.1) | 509 (36.8) | 998 (41.9) | 0.001 |
Urinary infection | 549 (30.8) | 409 (29.6) | 682 (28.6) | 0.323 |
Abdominal infection | 245 (13.7) | 159 (11.5) | 334 (14.0) | 0.072 |
Cerebral infection | 153 (8.5) | 106 (7.6) | 169 (7.1) | 0.206 |
Disease severity scores | ||||
SOFA on ICU admission median (IQR) | 6 (4–9) | 5 (4–8) | 5 (3–7) | <0.001 |
Maximum SOFA during ICU stay median (IQR) | 10 (7–14) | 9 (7–12) | 9 (7–12) | <0.001 |
Laboratory outcomes | ||||
Maximum serum creatinine (mg/L) | 2.5±2.7 | 2.2±2.1 | 2.1±1.9 | <0.001 |
Minimum haemoglobin level (g/dL) | 8.3±1.7 | 8.69±1.7 | 8.4±1.6 | <0.001 |
Maximum serum sodium (mmol/L) | 145.1±5.4 | 145.0±5.2 | 144.6±5.1 | 0.009 |
Maximum serum lactate (mmol/L) | 4.1±3.8 (n=1536) | 3.4±3.1 (n=1174) | 3.1±3.0 (n=2112) | <0.001 |
Platelet count (109/L) | 146.7±88.0 | 225.1±107.2 | 197.5±163.4 | <0.001 |
Lymphocyte count (109/L) | 2.1±5.7 | 1.1±0.5 | 0.68±0.4 | <0.001 |
PLR | 91.8±37.1 | 195.8±28.6 | 557.5±484.8 | <0.001 |
Clinical outcomes | ||||
ICU LOS | 9.9±10.1 | 9.3±8.7 | 10.1±9.9 | 0.071 |
Hospital LOS | 17.7±15.1 | 16.6±13.5 | 17.2±13.7 | 0.082 |
AKI, n (%) | 861 (48.3) | 601 (43.5) | 1080 (45.4) | 0.022 |
Hospital mortality, n (%) | 475 (26.6) | 291 (21.0) | 621 (26.1) | <0.001 |
AKI, acute kidney injury; BMI body mass index; CCU, coronary care unit; CSRU, cardiac surgery care unit; ICU, intensive care unit; LOS length of stay; MICU, multiple intensive care unit; PLR, platelet-to-lymphocyte ratio; SICU, surgical intensive care unit; SOFA, Sequential Organ Failure Assessment; TSICU, traumatic surgical intensive care unit