The molecular function (MF), biological process (BP) and reactome pathways of MUC1 in cancer
| Gene Ontology MF Complete | p53 binding, transcription coregulator activity, protein binding and RNA polymerase II proximal promoter sequence-specific DNA binding. |
| Gene Ontology BP complete | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, negative regulation of cell adhesion mediated by integrin, positive regulation of transcription from RNA polymerase II promoter in response to stress, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, negative regulation of transcription by competitive promoter binding, regulation of transcription from RNA polymerase II promoter in response to stress, cytokine-mediated signalling pathway, negative regulation of intrinsic apoptotic signalling pathway in response to DNA damage by p53 class mediator, O-glycan processing, positive regulation of histone H4 acetylation and stimulatory C-type lectin receptor signalling pathway |
| Reactome pathways | O-linked glycosylation of mucins, Metabolism of proteins, O-linked glycosylation, Defective C1GALT1C1 causes Tn polyagglutination syndrome, diseases of glycosylation, termination of O-glycan biosynthesis, defective GALNT3 causes familial hyperphosphatemic tumorous calcinosis, defective GALNT12 causes colorectal cancer 1, post-translational protein modification, disease, diseases associated with O-glycosylation of proteins. |