Table 2

Dose constraints for all trial arms

Volume	Arm A: Standard	Arm B: CHART-ED	Arm C: IDEAL-CRT	Arm D: I-START	Arm E: Isotoxic IMRT
CTV	V95%>99%	V95%>99%	V95%>99%	V95%>99%	Optimal: CTV D(total Vol −1 cc) ≥95% Mandatory: CTV^MeanDose±1% of prescribed dose
PTV	V95%>90% V90%>98%	V95%>90% V90%>98%	V95%>90% V90%>98%	V95%>90% V90%>98%	Optimal: PTV D(total vol −1 cc) ≥90% PTV D95%≥95% Mandatory: PTV D(total vol − 1 cc)≥85% PTV D95%≥90% PTV D1 cc≤107%
Spinal canal	D0.1 cc<47 Gy	D0.1 cc<46 Gy	D0.1 cc<48 Gy	D0.1 cc<47 Gy	D1.0 cc ≤ EQD2 50 Gy
Lung GTV	V20 Gy<35%	V20 Gy<35%	V20 Gy<35%		Mean dose≤20 Gy (physical dose)
Brachial plexus	D0.1 cc<55 Gy	D0.1 cc<64.3 Gy	D0.1 cc<65 Gy D30%<60 Gy (ipsilateral branchial plexus)	D0.1 cc<55 Gy	D1.0 cc ≤ EQD2 66 Gy
Heart	D100%<36 Gy D67%<44 Gy D33%<57 Gy	D100%<48 Gy D67%<57 Gy	D100%<44 Gy D67%<52 Gy D33%<59 Gy	D100%<36 Gy D67%<44 Gy D33%<57Gy	D1.0 cc ≤ EQD2 76 Gy Mean dose≤46 Gy (physical dose)
Oesophagus	D0.1 cc<105%	D0.1 cc<105%	D1.0 cc<65 Gy
Lung contra	V5 Gy<60%*		V5 Gy<60%*	V5 Gy<60%*
Mediastinal envelope					D1.0 cc ≤ EQD2 76 Gy

*Optimal constraint (ie, not mandatory limit).
CTV, clinical target volume; EQD2, equivalent dose for 2 Gray fractions; GTV, gross tumour volume; IMRT, intensity-modulated radiotherapy; PTV, planning target volume.