Table 1

Summary of trial arms

Trial armTotal dose (Gy)Total fractionsFractions per dayTotal number of days
Arm A: Standard55.020126–28
Arm B: CHART-ED54.0363Days 1–12
10.862Days 15–17
Arm C: IDEAL-CRT63–71301 with 1 twice daily treatment per week33–35
Arm D: I-START55–6520126–28
Arm E: Isotoxic IMRT61.2–79.234–44223–30 depending on dose escalation