Week 0 (baseline)* | Week 3† | Week 6† | |||
Δ (95% CI) | Δ (95% CI) | P value | Δ (95% CI) | P value | |
Hot flushes | 0.1 (−0.6 to 0.7) | −1.5 (−2.2 to −0.7) | 0.0002‡ | −1.6 (−2.3 to −0.8) | <0.0001‡ |
Day-and-night sweats | 0.0 (− 0.9 to 0.8) | −1 (−1.8 to −0.1) | 0.024 | −1.2 (−2.0 to −0.4) | 0.0056‡ |
General sweating | 0.0 (−0.6 to 0.6) | −0.6 (−1.3 to 0.1) | 0.091 | −0.9 (−1.6 to −0.2) | 0.0086‡ |
Menopausal-specific sleeping problems | 0.2 (−0.5 to 1) | −0.9 (−1.7;- 0.1) | 0.033 | −1.8 (−2.7 to −1.0) | <0.0001‡ |
Emotional symptoms | 1.0 (−1.5 to 3.5) | −3.2 (−5.1 to −1.2) | 0.0015‡ | −3.4 (−5.3 to −1.4) | 0.0008‡ |
Memory changes | −0.2 (−0.8 to 0.4) | −0.5 (−1.0 to 0.1) | 0.11 | −0.2 (−0.8 to 0.1) | 0.49 |
Physical symptoms | 0.1 (−1.5 to 1.6) | −1.3 (−2.6;- 0.0) | 0.049 | −1.7 (−3 to −0.4) | 0.010‡ |
Urinary and vaginal symptoms | 0.8 (0.1 to 1.5) | −0.4 (−1.1 to 0.3) | 0.21 | −0.8 (−1.5 to −0.1) | 0.025 |
Abdominal symptoms | 0.1 (−0.6 to 0.8) | −0.3 (−1 to 0.4) | 0.38 | −0.7 (−1.4 to 0.0) | 0.042 |
Skin and hair symptoms | 0.3 (−0.7 to 1.4) | −1.4 (−2.4 to −0.5) | 0.0036‡ | −1.5 (−2.5 to −0.6) | 0.0021‡ |
Sexual symptoms | −0.2 (−1 to 0.7) | −0.7 (−1.4 to −0.1) | 0.032 | −0.3 (−0.8 to 0.5) | 0.69 |
Tiredness | 0.1 (−0.3 to 0.5) | −0.3 (−0.8 to 0.1) | 0.15 | −0.5 (−0.9 to 0.0) | 0.049 |
Differences in mean scores between the randomization groups at each of the follow-up time points.
Negative values Δ=less symptoms in the intervention group.
*Difference in mean score of intervention relative to control, adjusted for stratification factors (age and level of symptoms [‘quite a bit’ or ‘a lot’ HF]).
†Difference in mean score of intervention relative to control beyond the difference already present at week 0 (baseline), adjusted for stratification factors (age and level of symptoms [‘quite a bit’ or ‘a lot’ HF]).
‡Significant at a 0.01 level to control for the false discovery rate at 0.05.