Table 3

Differences in means, primary and secondary outcomes

Week 0 (baseline)*Week 3†Week 6†
Δ (95% CI)Δ (95% CI)P valueΔ (95% CI)P value
Hot flushes0.1 (−0.6 to 0.7)−1.5 (−2.2 to −0.7)0.0002‡−1.6 (−2.3 to −0.8)<0.0001‡
Day-and-night sweats0.0 (− 0.9 to 0.8)−1 (−1.8 to −0.1)0.024−1.2 (−2.0 to −0.4)0.0056‡
General sweating0.0 (−0.6 to 0.6)−0.6 (−1.3 to 0.1)0.091−0.9 (−1.6 to −0.2)0.0086‡
Menopausal-specific sleeping problems0.2 (−0.5 to 1)−0.9 (−1.7;- 0.1)0.033−1.8 (−2.7 to −1.0)<0.0001‡
Emotional symptoms1.0 (−1.5 to 3.5)−3.2 (−5.1 to −1.2)0.0015‡−3.4 (−5.3 to −1.4)0.0008‡
Memory changes−0.2 (−0.8 to 0.4)−0.5 (−1.0 to 0.1)0.11−0.2 (−0.8 to 0.1)0.49
Physical symptoms0.1 (−1.5 to 1.6)−1.3 (−2.6;- 0.0)0.049−1.7 (−3 to −0.4)0.010‡
Urinary and vaginal symptoms0.8 (0.1 to 1.5)−0.4 (−1.1 to 0.3)0.21−0.8 (−1.5 to −0.1)0.025
Abdominal symptoms0.1 (−0.6 to 0.8)−0.3 (−1 to 0.4)0.38−0.7 (−1.4 to 0.0)0.042
Skin and hair symptoms0.3 (−0.7 to 1.4)−1.4 (−2.4 to −0.5)0.0036‡−1.5 (−2.5 to −0.6)0.0021‡
Sexual symptoms−0.2 (−1 to 0.7)−0.7 (−1.4 to −0.1)0.032−0.3 (−0.8 to 0.5)0.69
Tiredness0.1 (−0.3 to 0.5)−0.3 (−0.8 to 0.1)0.15−0.5 (−0.9 to 0.0)0.049
  • Differences in mean scores between the randomization groups at each of the follow-up time points.

  • Negative values Δ=less symptoms in the intervention group.

  • *Difference in mean score of intervention relative to control, adjusted for stratification factors (age and level of symptoms [‘quite a bit’ or ‘a lot’ HF]).

  • †Difference in mean score of intervention relative to control beyond the difference already present at week 0 (baseline), adjusted for stratification factors (age and level of symptoms [‘quite a bit’ or ‘a lot’ HF]).

  • ‡Significant at a 0.01 level to control for the false discovery rate at 0.05.