Standardised indirect effects and ratio of indirect to total effects for the paths on the SMMs
| Indirect effects of pain on HRQoL | Ratio of indirect to total effect | |||
| b (boot SE) | BC 95% CI (LL-UL)* | b (boot SE) | BC 95% CI (LL-UL)* | |
| SMM1: PN ->AXT ->DEP ->FTG ->HRQoL | ||||
| PN ->AXT ->HRQoL | −0.138 (0.057) | (−0.268 to –0.04) | 0.299 (0.126) | (0.082 to 0581) |
| PN ->AXT ->DEP ->HRQoL | −0.042 (0.033) | (−0.109 to 0.022) | 0.091 (0.074) | (−0.049 to 0.239) |
| PN ->AXT ->FTG ->HRQoL | −0.108 (0.032) | (−0.186 to –0.057) | 0.234 (0.077) | (0.114 to 0.424) |
| PN ->AXT ->DEP ->FTG ->HRQoL | −0.004 (0.01) | (−0.028 to 0.013) | 0.009 (0.022) | (−0.029 to 0.063) |
| PN ->DEP ->HRQoL | −0.018 (0.018) | (−0.069 to 0.005) | 0.04 (0.04) | (−0.012 to 0.153) |
| PN ->DEP ->FTG ->HRQoL | −0.002 (0.005) | (−0.019 to 0.005) | 0.004 (0.011) | (−0.01 to 0.041) |
| PN ->FTG ->HRQoL | −0.071 (0.024) | (−0.13 to –0.033) | 0.154 (0.056) | (0.07 to 0.296) |
| SMM2: PN ->FTG ->AXT DEP ->HRQoL | ||||
| PN ->FTG ->HRQoL | −0.186 (0.042) | (−0.272 to –0.11) | 0.299 (0.126) | (0.082 to 0.581) |
| PN ->FTG ->AXT ->HRQoL | −0.074 (0.032) | (−0.146 to –0.023) | 0.244 (0.077) | (0.119 to 0.427) |
| PN ->FTG ->DEP ->HRQoL | −0.002 (0.006) | (−0.022 to 0.006) | 0.088 (0.074) | (−0.047 to 0.241) |
| PN ->FTG ->AXT ->DEP ->HRQoL | −0.022 (0.018) | (−0.063 to 0.011) | 0.003 (0.008) | (−0.007 to 0.029) |
| PN ->AXT ->HRQoL | −0.064 (0.03) | (−0.141 to –0.018) | 0.158 (0.058) | (0.071 to 0.304) |
| PN ->AXT ->DEP ->HRQoL | −0.019 (0.017) | (−0.062 to 0.008) | 0.002 (0.005) | (−0.004 to 0.024) |
| PN ->DEP ->HRQoL | −0.018 (0.017) | (−0.067 to 0.005) | 0.038 (0.039) | (−0.012 to 0.147) |
| SMM3: PN ->DEP> AXT ->FTG->HRQoL | ||||
| PN ->DEP ->HRQoL | −0.061 (0.048) | (−0.156 to 0.03) | 0.131 (0.106) | (−0.072 to 0.343) |
| PN ->DEP ->AXT ->HRQoL | −0.074 (0.031) | (−0.15 to –0.021) | 0.161 (0.07) | (0.044 to 0.324) |
| PN ->DEP ->FTG ->HRQoL | −0.006 (0.015) | (−0.043 to 0.018) | 0.014 (0.032) | (−0.038 to 0.094) |
| PN ->DEP ->AXT ->FTG ->HRQoL | −0.058 (0.019) | (−0.105 to –0.028) | 0.126 (0.047) | (0.057 to 0.248) |
| PN ->AXT ->HRQoL | −0.064 (0.029) | (−0.138 to –0.019) | 0.138 (0.065) | (0.042 to 0.306) |
| PN ->AXT ->FTG ->HRQoL | −0.05 (0.017) | (−0.094 to –0.025) | 0.108 (0.038) | (0.053 to 0.212) |
| PN ->FTG ->HRQoL | −0.071 (0.024) | (−0.13 to –0.033) | 0.154 (0.056) | (0.07 to 0.296) |
| SMM4: PN ->AXT ->FTG ->DEP> ->HRQoL | ||||
| PN ->AXT ->HRQoL | −0.138 (0.056) | (−0.262 to –0,04) | 0.299 (0.125) | (0.076 to 0.578) |
| PN ->AXT ->FTG ->HRQoL | −0.113 (0.031) | (−0.187 to –0061) | 0.244 (0.076) | (0.122 to 0.426) |
| PN ->AXT ->DEP ->HRQoL | −0.041 (0.034) | (−0.115 to 0.02) | 0.088 (0.075) | (−0.045 to 0.259) |
| PN ->AXT ->FTG ->DEP ->HRQoL | −0.001 (0.004) | (−0.013 to 0.003) | 0.003 (0.008) | (−0.007 to 0.028) |
| PN ->FTG ->HRQoL | −0.073 (0.025) | (−0.131 to –0.031) | 0.158 (0.058) | (0.065 to 0.299) |
| PN ->FTG ->DEP ->HRQoL | −0.001 (0.003) | (−0.011 to 0.002) | 0.002 (0.006) | (−0.004 to 0.022) |
| PN ->DEP ->HRQoL | −0.018 (0.017) | (−0.067 to 0.005) | 0.038 (0.039) | (−0.01 to 0.152) |
| SMM5: PN ->FTG ->DEP> AXT ->HRQoL | ||||
| PN ->FTG ->HRQoL | −0.186 (0.042) | (−0.272 to –0.11) | 0.402 (0.103) | (0.223 to 0.632) |
| PN ->FTG ->DEP ->HRQoL | −0.024 (0.019) | (−0.064 to 0.011) | 0.052 (0.042) | (−0.023 to 0.146) |
| PN ->FTG ->AXT ->HRQoL | −0.052 (0.023) | (−0.106 to –0.016) | 0.112 (0.051) | (0.031 to 0.23) |
| PN ->FTG ->DEP ->AXT ->HRQoL | −0.022 (0.011) | (−0.05 to –0.007) | 0.049 (0.024) | (0.015 to 0.11) |
| PN ->DEP ->HRQoL | −0.036 (0.031) | (−0.106 to 0.016) | 0.079 (0.069) | (−0.034 to 0.238) |
| PN ->DEP ->AXT ->HRQoL | −0.034 (0.015) | (−0.07 to –0.01) | 0.073 (0.034) | (0.021 to 0.156) |
| PN ->AXT ->HRQoL | −0.03 (0.019) | (−0.082 to –0.004) | 0.065 (0.042) | (0.008 to 0.181) |
| SMM6: PN ->DEP> FTG ->AXT ->HRQoL | ||||
| PN ->DEP ->HRQoL | −0.061 (0.048) | (−0.158 to 0.029) | 0.131 (0.107) | (−0.065 to 0.355) |
| PN ->DEP ->FTG ->HRQoL | −0 .065 (0.023) | (−0.12 to –0.03) | 0.14 (0.054) | (0.062 to 0.283) |
| PN ->DEP ->AXT ->HRQoL | −0.056 (0.023) | (−0.111 to –0.017) | 0.122 (0.053) | (0.033 to 0.245) |
| PN ->DEP ->FTG ->AXT ->HRQoL | −0.018 (0.009) | (−0.043 to –0.006) | 0.039 (0.021) | (0.011 to 0.096) |
| PN ->FTG ->HRQoL | −0.121 (0.031) | (−0.192 to –0.07) | 0.262 (0.073) | (0.146 to 0.44) |
| PN ->FTG ->AXT ->HRQoL | −0.034 (0.016) | (−0.073 to –0.011) | 0.073 (0.035) | (0.021 to 0.16) |
| PN ->AXT ->HRQoL | −0.03 (0.019) | (−0.082 to –0.004) | 0.065 (0.042) | (0.008 to 0.181) |
Table shows standardised indirect effects with bootstrapped SEs; Paths in bold indicate statistically significant indirect effects.
∫ Bias-corrected 95% CIs.
*LL- Lower Limit, UL- Upper Limit
AXT, anxiety; DEP, depression; FTG, fatigue; HRQoL, health-related quality of life; PN, pain; SMM, serial mediation model.