Table 4

Summary of neurocognitive test scores at baseline, 30 days and 12 months

TAVIBaseline 30 daysP value* 12 monthsP value
MMSE Lotus
CoreValve
28.6±1.6
28.8±1.8
28.8±1.8
28.4±2.0
0.468
0.251
28.7±2.0
27.9±2.8
0.743
0.277
HVLT
Total learningLotus21.4±7.221.5±4.10.91323.3±6.10.104
CoreValve17.7±6.318.6±6.10.51218.3±7.80.764
Delayed recallLotus7.6±3.06.3±3.4 0.038 9.0±6.7 0.028
CoreValve5.8±2.85.3±3.80.2964.3±4.40.419
Discrimination IndexLotus10.2±1.58.6±2.9 0.015 10.1±2.4 0.010
CoreValve9.6±2.19.1±3.40.3737.9±4.50.147
Trail Making Tests
ALotus47.0±15.056.0±27.60.11250.5±19.70.354
CoreValve56.9±27.861.1±40.00.56666.1±49.80.431
BLotus170.9±86.5140.7±62.8 0.006 152.3±87.50.273
CoreValve171.1±121.4155.2±79.00.548143.3±64.40.969
DSST Lotus43.2±15.845.5±16.00.25444.2±13.50.253
CoreValve33.9±14.134.6±13.30.70434.4±15.70.633
LNS Lotus
CoreValve
7.6±4.5
8.3±5.1
8.6±3.5
8.8±4.2
0.387
0.662
8.6±2.6
7.9±4.8
0.876
0.291
Grooved pegboard
Dominant scoreLotus
CoreValve
163.1±102.4
157.3±57.2
136.9±75.7
132.1±81.3
0.336
0.162
142.7±38.0
169.0±60.4
0.670
0.110
Non-dominant scoreLotus
CoreValve
158.0±37.7
180.9±58.2
148.5±53.4
173.9±104.2
0.373
0.654
159.6±47.0
215.9±124.4
0.658
0.004
  • Mean±SD.

  • *Comparing values at baseline and 30 days, same TAVI design, paired samples t-test.

  • †Comparing values at 30 days and 12 months, same TAVI design, paired samples t-test.

  • DSST, Digit-Symbol Substitution Test; HVLT, Hopkins Verbal Learning Test; LNS, Letter Number Sequencing; MMSE, Mini-Mental State Examination; TAVI, transcatheter aortic valve implantation.