Table 5

Within-group comparison of mean change in cognitive domain over 12 months in patients with and without diffusion-weighted (DW) MRI lesions

Boston Lotus (n=25)Medtronic CoreValve (n=24)
DWI −ve (n=6)DWI +ve (n=19)P valueDWI –ve (n=11)DWI +ve (n=13)P value
MMSE1.2±0.8−0.4±1.9 0.025 −0.9±2.5−0.7±2.60.840
HVLT learning4.2±5.21.2±7.30.4541.1±3.91.0±9.10.691
HVLT delayed6.3±12.9−0.1±3.30.177−0.2±2.5−1.1±3.10.456
HVLT discrimination0.0±1.5−0.1±2.60.7330.8±2.3−2.3±3.5 0.019
TMT A15.5±20.8−0.1±15.30.05918.9±64.95.0±14.70.562
TMT B−13.0±88.9−18.3±61.40.87019.6±61.6−1.4±64.40.454
DSST4.0±10.0−0.4±9.80.346−0.1±6.75.0±13.70.370
LNS2.4±3.00.7±5.10.534−0.5±5.00.8±3.60.474
GPBT dominant−8.2±31.5−24.5±108.00.7210.5±37.622.6±37.70.186
GPBT non-dominant−26.0±83.7−3.2±51.30.91443.0±81.320.8±66.80.235
  • Mean±SD.

  • DSST, Digit-Symbol Substitution Test; DWI, diffusion-weighted imaging; GPBT, Grooved Pegboard Test; HVLT, Hopkins Verbal Learning Test; LNS, Letter Number Sequencing; MMSE, Mini-Mental State Examination; TMT, Trail Making Test.