Effect of pregabalin on sleep scores in patients with neuropathic pain
|
Patient or population: patients with neuropathic pain Settings: Intervention: effect of pregabalin on sleep | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No. of participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| Control | Effect of pregabalin on sleep | |||||
| Sleep interference | The mean sleep interference in the intervention groups was 0.38 SD lower (0.5–0.26 lower). | 1641 (seven studies). | ⊕⊕⊕⊝ Moderate† | SMD −0.38 (−0.5 to −0.26). | ||
GRADE Working Group grades of evidence.
High quality: further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality: further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low quality: further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality: we are very uncertain about the estimate.
*The basis for the assumed risk (eg, the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
†Selective reporting, authors had financial ties to industry sponsor.
GRADE, Grading of Recommendation, Assessment, Development, and Evaluation; SMD, standardised mean difference.