ETTH and CTTH drug monotherapies list
| Subtype of TTH | Drug classification | Drug treatment |
| ETTH | Non-steroidal anti-inflammatory drugs | Aspirin/acetylsalicylic acid |
| Acetaminophen/paracetamol | ||
| Lumiracoxib | ||
| Ibuprofen | ||
| Ketoprofen | ||
| Naproxen | ||
| Diclofenac | ||
| Diclofenac-K | ||
| Metamizole/Dipyrone | ||
| Analgesics | Codeine | |
| Dihydrocodeine | ||
| Dextropropoxyphene | ||
| Antiemetics | Metoclopramide | |
| Chlorpromazine | ||
| Supplementary | Tiger balm | |
| CTTH | Antidepressants | Amitriptyline |
| L-5-Hydroxytryptophan | ||
| Fluvoxamine | ||
| Venlafaxine | ||
| Clomipramine | ||
| Mirtazapine | ||
| Maprotiline | ||
| Mianserin | ||
| Desipramine | ||
| Fluoxetine | ||
| Paroxetine | ||
| Nefazodone | ||
| Ritanserin | ||
| Sulpiride | ||
| Dothiepin/Prothiaden | ||
| Nortriptyline | ||
| Protriptyline | ||
| Antiepileptics | Sodium valproate | |
| Topiramate | ||
| Gabapentin | ||
| Levetiracetam | ||
| Anxiolytics | Diazepam/Valium | |
| Alprazolam | ||
| Buspirone | ||
| Narcotics | Tizanidine | |
| Cyclobenzaprine | ||
| Botulinum toxin A/OnabotulinumtoxinA |
CTTH, chronic TTH; ETTH, episodic TTH; TTH, tension-type headache.