Potential treatment effect modifiers
| Characteristic | Description |
| Gender | Male vs female |
| Menopausal status | Premenopausal vs postmenopausal |
| Age (years) | Continuous variable |
| Body mass index* (BMI) | BMI ≥30 (obese) vs <30 (non-obese) |
| Radiographic osteoarthritis (OA) stage | Radiographic minimum joint space width (continuous); Kellgren Lawrence grade |
| Baseline knee pain severity | Continuous variable |
| Bone marrow lesion (BML) | Presence of at least one moderate to large BML vs absence of presence of small BML |
| Baseline levels of systemic markers of bone turnover (eg, CTX-I, CTX-II and NTX-I) | ≥ mean value vs < mean value† |
| Systemic bone density status | Either as continuous variable or presence vs absence of osteopenia/osteoporosis |
*Measured in kg m-2.
†Values will be standardised if the distribution is skewed.