Table 4

Results of genetic association analyses of different renal function indices

SNPChr: BPGeneA1/A2* MAF_%Beta SEP value
Blood urea
rs11868441 17: 59239221 BCAS3 A/G30.1−0.0380.0150.014
rs1892172 6: 127476516 RSPO3 T/C46.90.0310.0140.028
rs4644087 6: 127481154 RSPO3 C/A46.80.0300.0140.03
rs4382293 6: 127475433 RSPO3 G/A47.00.0300.0140.03
rs2489629 6: 127476717 RSPO3 G/A44.9−0.0290.0140.039
Serum creatinine
rs6999484 8: 23728271 STC1-ADAM28 A/G23.80.0330.0110.003
rs1705699 8: 23781453 STC1-ADAM28 G/A24.20.0310.0110.005
rs2828785 21: 25437505 - A/G19.9−0.0300.0110.008
rs11227279 11: 65495211 KRT8P26-AP5B1 A/G28.4−0.0240.0100.019
rs7785065 7: 32915204 KBTBD2 A/C43.50.0220.0100.022
rs4859682 4: 77410318 SHROOM3 A/C25.70.0210.0100.034
rs1031755 15: 53951435 WDR72 C/A11.7−0.0290.0140.038
rs7740534 6: 25077179 - C/A9.6−0.0320.0150.042
Estimated glomerular filtration rate
rs2168785 17: 37407135 MED1 G/A28.2−4.2991.7540.015
rs12452509 17: 37574722 MED1 G/A28.1−4.2321.7570.017
rs4776168 15: 53936907 WDR72 G/A10.85.8282.6990.031
rs10518733 15: 53940307 WDR72 C/A10.85.8282.6990.031
rs7541937 1: 35341982 DLGAP3 C/A44.03.5901.6930.035
rs10032549 4: 77398015 SHROOM3 G/A32.2−3.6551.7500.037
rs2484639 1: 243462367 SDCCAG8 A/G43.53.3781.6560.042
Vitamin D(25-OH cholecalciferol)
rs1801725 3: 122003757 CASR A/C22.6−6.9232.5840.008
rs1155563 4: 72643488 GC G/A18.9−6.9512.6080.008
rs12794714 11: 14913575 CYP2R1 A/G41.5−5.1102.0990.015
rs10500804 11: 14910273 CYP2R1 C/A42.2−5.0042.0600.016
Albumin:creatinine ratio
rs4528660 18: 3043516 LPIN2-MYOM1 G/A17.8−0.3230.1440.027
  • *A1/A2: minor to major alleles.

  • †Beta: regression coefficient for the linear regression model, calculated based on A1 (the minor allele).

  • BP, base pair position; Chr, chromosome; MAF, minor allele frequency; SNP, single nucleotide polymorphism.