Number, publication status and patient enrolment of registered and completed studies on paediatric mechanical ventilation and ventilator-induced lung injury (VILI)
| Overall no of studies | No of published studies, n (%) | Overall enrolment | Enrolment in published studies, n (%) | No of randomised studies, n (%) | No of published randomised studies, n (%) | Enrolment in randomised studies | Enrolment in published randomised studies, n (%) | |
| Age distribution | ||||||||
| Total | 109 | 77 (70.6) | 22 233 | 18 647 (83.9) | 65 (59.6) | 45 (69.2) | 15 872 | 13 493 (85.0) |
| Including children below 1 year | 84 | 59 (70.2) | 18 719 | 15 421 (82.4) | 53 (63.1) | 39 (73.6) | 13 990 | 11 869 (84.8) |
| Including children between 1 and 14 years | 23 | 11 (47.8) | 5197 | 4158 (80.0) | 14 (60.9) | 5 (35.7) | 3434 | 2703 (78.7) |
| Including children older than 14 years | 36 | 21 (58.3) | 7060 | 5964 (84.5) | 20 (55.6) | 9 (45.0) | 4985 | 4227 (84.8) |
| Exclusively including children below 1 year | 66 | 50 (75.8) | 13 693 | 11 293 (82.5) | 42 (63.6) | 34 (80.9) | 10 697 | 9166 (85.7) |
| Exclusively including children between 1 and 14 years | 2 | 2 (100) | 30 | 30 (100) | 0 (0.00) | 0 (0.00) | 0 | 0 (0.0) |
| Research study subtopics | ||||||||
| Biophysical and technical issues | 32 | 25 (78.1) | 4653 | 4239 (91.1) | 17 (53.1) | 14 (82.4) | 3091 | 2947 (95.3) |
| Drug application in mechanical ventilation to counteract VILI | 40 | 33 (82.5) | 8774 | 8482 (96.7) | 28 (70.0) | 23 (82.1) | 6743 | 6469 (95.9) |
| Diagnostic issues | 16 | 10 (62.5) | 2680 | 1335 (49.8) | 4 (25.0) | 2 (50.0) | 1584 | 565 (35.7) |
| Weaning and extubation success | 11 | 6 (54.5) | 2123 | 1885 (88.8) | 8 (72.7) | 4 (50.0) | 1413 | 1196 (84.6) |
| Follow-up | 12 | 7 (58.3) | 3537 | 2922 (82.6) | 5 (41.7) | 3 (60.0) | 1995 | 1791 (89.8) |
| Additional items of analysis | ||||||||
| Studies including application of anti-inflammatory drugs | 13 | 10 (76.9) | 2660 | 2499 (93.9) | 12 (92.3) | 9 (75.0) | 2630 | 2469 (93.9) |
| Miscellaneous | 19 | 13 (68.4) | 6421 | 5696 (88.7) | 9 (47.4) | 5 (55.6) | 4175 | 3450 (82.6) |