Table 6

Level 4: Crude incidence rates (IR; per 1000 person-years) and adjusted HR for severe retinopathy, nephropathy, neuropathy* and cardiovascular disease by demographic factors among people with type 2 diabetes treated at outpatient hospital departments in the Greater Copenhagen area

Severe retinopathy
(1007 events/60 889 PY)
Nephropathy
(859 events/46 366 PY)
Neuropathy
(800 events/45.230 PY)
Cardiovascular disease
(2218 events/38 636 PY)
IR (95% CI)HR (95% CI)†IR (95% CI)HR (95% CI)†IR (95% CI)HR (95% CI)†IR (95% CI)HR (95% CI)†
Overall16.5 (15.5 to 17.6)18.5 (17.3 to 19.8)17.7 (16.5 to 19.0)57.4 (55.1 to 59.8)
Sex
 Women16.8 (15.3 to 18.4)Ref15.8 (14.2 to 17.6)Ref15.6 (14.0 to 17.5)Ref53.7 (50.4 to 57.2)Ref
 Men16.4 (15.1 to 17.8)1.10 (0.93 to 1.30)20.7 (19.0 to 22.5)1.27 (1.05 to 1.54)19.2 (17.6 to 21.0)1.24 (1.03 to 1.50)60.6 (57.3 to 64.1)1.25 (1.11 to 1.40)
Age (years)
 17–449.1 (7.0 to 11.9)0.80 (0.56 to 1.15)8.1 (5.9 to 10.9)0.75 (0.49 to 1.13)8.6 (6.5 to 11.6)0.54 (0.35 to 0.84)25.1 (21.1 to 29.8)0.49 (0.38 to 0.63)
 45–6414.7 (13.4 to 16.1)Ref16.0 (14.5 to 17.7)Ref16.3 (14.8 to 18.0)Ref49.0 (46.2 to 52.1)Ref
 65+20.8 (19.1 to 22.7)1.20 (1.01 to 1.44)25.5 (23.2 to 28.1)1.75 (1.43 to 2.13)22.7 (20.5 to 25.2)1.21 (1.00 to 1.47)87.0 (81.8 to 92.5)1.72 (1.52 to 1.94)
Region of origin
 Denmark15.6 (14.6 to 16.8)Ref19.1 (17.8 to 20.6)Ref18.9 (17.5 to 20.4)Ref59.3 (56.6 to 62.1)Ref
 Europe19.7 (15.3 to 25.4)1.32 (0.96 to 1.83)15.1 (10.9 to 20.9)0.60 (0.37 to 0.98)14.0 (10.0 to 19.6)0.67 (0.42 to 1.06)51.7 (42.5 to 62.8)0.91 (0.70 to 1.19)
 Sub-Saharan Africa9.6 (4.3 to 21.5)1.25 (0.51 to 3.03)9.5 (3.9 to 22.7)0.31 (0.04 to 2.20)17.4 (9.0 to 33.3)1.23 (0.50 to 2.98)32.9 (20.5 to 52.9)0.64 (0.31 to 1.36)
 Middle East and North Africa21.2 (18.1 to 24.8)1.42 (1.13 to 1.79)17.3 (14.3 to 21.0)0.95 (0.71 to 1.27)14.1 (11.4 to 17.4)0.79 (0.58 to 1.08)54.2 (48.2 to 60.9)1.04 (0.87 to 1.24)
 Asia21.3 (14.3 to 31.8)0.99 (0.51 to 1.93)18.3 (11.2 to 29.8)1.46 (0.77 to 2.76)9.9 (5.1 to 19.0)0.43 (0.16 to 1.14)35.9 (25.1 to 51.4)0.64 (0.38 to 1.09)
 America and Oceania11.5 (3.7 to 35.6)0.51 (0.07 to 3.66)4.4 (0.6 to 30.9)Insufficient data4.8 (0.7 to 34.1)Insufficient data53.0 (26.5 to 105.9)0.95 (0.35 to 2.53)
  • *Analyses were only based on data from hospital-treated patients, because it is known that some diagnostic codes are not used by the general practitioners (GP). Using only data from outpatient clinics will result in fewer events and person-years, but are likely to reflect a closer estimate of the actual expected incidence rates.

  • †Adjusted HR from Cox regression models with duration of diabetes as time scale and controlling for age, diabetes type, HbA1c, body mass index (BMI), blood pressure, lipids and smoking at baseline.

  • PY, person-years.